FAM195B The phosphorylation status of MCRIP1 functions as a molecular switch to regulate epithelial-mesenchymal transition. Unphosphorylated MCRIP1 binds to and inhibits the transcriptional corepressor CTBP(s). When phosphorylated by MAPK/ERK, MCRIP1 releases CTBP(s) resulting in transcriptional silencing of the E-cadherin gene and induction of epithelial-mesenchymal transition. Belongs to the MCRIP family. Note: This description may include information from UniProtKB.
Chromosomal Location of Human Ortholog: 11|11 E2
Cellular Component:  cytoplasm; cytoplasmic stress granule; nucleus
Biological Process:  regulation of epithelial to mesenchymal transition
Reference #:  Q3UGS4 (UniProtKB)
Alt. Names/Synonyms: BC003940; BC003940 protein; F195B; Fam195; Fam195b; family with sequence similarity 195, member B; hypothetical protein LOC192173; MAPK regulated corepressor interacting protein 1; Mapk-regulated corepressor-interacting protein 1; MCRI1; Mcrip1; OTTMUSP00000004663; Protein FAM195B
Gene Symbols: Fam195b
Molecular weight: 11,101 Da
Basal Isoelectric point: 9.2  Predict pI for various phosphorylation states
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene