AMOTL1 Inhibits the Wnt/beta-catenin signaling pathway, probably by recruiting CTNNB1 to recycling endosomes and hence preventing its translocation to the nucleus. Belongs to the angiomotin family. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Adaptor/scaffold
Chromosomal Location of Human Ortholog: 9|9 A2
Cellular Component:  apical plasma membrane; bicellular tight junction; cell junction; cytoplasmic vesicle; lamellipodium
Molecular Function:  identical protein binding; protein binding
Biological Process:  actin cytoskeleton organization; angiogenesis; establishment of cell polarity involved in ameboidal cell migration; hippo signaling; positive regulation of blood vessel endothelial cell migration; regulation of cell migration; Wnt signaling pathway
Reference #:  Q9D4H4 (UniProtKB)
Alt. Names/Synonyms: 2310010G08Rik; 2310067L22Rik; 4932416D09Rik; AMOL1; Amotl1; angiomotin-like 1; Angiomotin-like protein 1; FLJ00155; JEAP; mFLJ00155
Gene Symbols: Amotl1
Molecular weight: 107,950 Da
Basal Isoelectric point: 6.94  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene