CRMP-1 Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance, invasive growth and cell migration. May participate in cytokinesis. Belongs to the metallo-dependent hydrolases superfamily. Hydantoinase/dihydropyrimidinase family. Brain. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Cell development/differentiation; Cytoskeletal; Hydrolase
Chromosomal Location of Human Ortholog: 4p16.2
Cellular Component:  centrosome; cytosol; midbody; nucleus; spindle
Molecular Function:  filamin binding; hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds; protein binding
Biological Process:  axon guidance; microtubule cytoskeleton organization; negative regulation of actin filament binding; negative regulation of neuron projection development; nervous system development; nucleobase-containing compound metabolic process
Reference #:  Q14194 (UniProtKB)
Alt. Names/Synonyms: Collapsin response mediator protein 1; CRMP-1; CRMP1; dihydropyrimidinase related protein-1; dihydropyrimidinase-like 1; Dihydropyrimidinase-related protein 1; DPYL1; DPYSL1; DRP-1; DRP1; ULIP-3; ULIP3; Unc-33-like phosphoprotein 3
Gene Symbols: CRMP1
Molecular weight: 62,184 Da
Basal Isoelectric point: 6.55  Predict pI for various phosphorylation states
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CRMP-1

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  InnateDB