CLASP2 Microtubule plus-end tracking protein that promotes the stabilization of dynamic microtubules. Involved in the nucleation of noncentrosomal microtubules originating from the trans-Golgi network (TGN). Required for the polarization of the cytoplasmic microtubule arrays in migrating cells towards the leading edge of the cell. May act at the cell cortex to enhance the frequency of rescue of depolymerizing microtubules by attaching their plus-ends to cortical platforms composed of ERC1 and PHLDB2. This cortical microtubule stabilizing activity is regulated at least in part by phosphatidylinositol 3-kinase signaling. Also performs a similar stabilizing function at the kinetochore which is essential for the bipolar alignment of chromosomes on the mitotic spindle. Acts as a mediator of ERBB2-dependent stabilization of microtubules at the cell cortex. Belongs to the CLASP family. Brain-specific. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Cytoskeletal; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 3p22.3
Cellular Component:  basal cortex; cell cortex; cell leading edge; condensed chromosome kinetochore; cytoplasm; cytoplasmic microtubule; cytosol; Golgi apparatus; kinetochore microtubule; microtubule; microtubule organizing center; plasma membrane; ruffle membrane; trans-Golgi network
Molecular Function:  dystroglycan binding; microtubule binding; microtubule plus-end binding; protein binding
Biological Process:  cell division; establishment or maintenance of cell polarity; exit from mitosis; Golgi organization; microtubule anchoring; microtubule cytoskeleton organization; microtubule nucleation; microtubule organizing center organization; mitotic spindle organization; negative regulation of focal adhesion assembly; negative regulation of microtubule depolymerization; negative regulation of stress fiber assembly; negative regulation of wound healing, spreading of epidermal cells; positive regulation of basement membrane assembly involved in embryonic body morphogenesis; positive regulation of epithelial cell migration; positive regulation of exocytosis; positive regulation of extracellular matrix disassembly; protein localization to plasma membrane; regulation of epithelial to mesenchymal transition; regulation of gastrulation; regulation of microtubule polymerization or depolymerization; regulation of microtubule-based process; vesicle targeting
Reference #:  O75122 (UniProtKB)
Alt. Names/Synonyms: CLAP2; CLASP2; CLIP-associating protein 2; cytoplasmic linker associated protein 2; Cytoplasmic linker-associated protein 2; hOrbit2; KIAA0627; multiple asters (Mast)-like homolog 2; Protein Orbit homolog 2
Gene Symbols: CLASP2
Molecular weight: 141,064 Da
Basal Isoelectric point: 8.62  Predict pI for various phosphorylation states
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

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