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ADAM18
Sperm surface membrane protein that may be involved in spermatogenesis and fertilization. This is a non catalytic metalloprotease-like protein. Expressed specifically in testis. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: Cell adhesion; Membrane protein, integral; Motility/polarity/chemotaxis |
| Chromosomal Location of human Ortholog: 8p11.22 |
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Cellular Component:
membrane; plasma membrane
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Molecular Function:
metalloendopeptidase activity; metallopeptidase activity
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Biological Process:
binding of sperm to zona pellucida; cell adhesion; cell differentiation; male gonad development; proteolysis; spermatogenesis
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Reference #:
Q9Y3Q7
(UniProtKB)
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Alt. Names/Synonyms: a disintegrin and metalloproteinase domain 18; ADA18; ADAM 18; ADAM metallopeptidase domain 18; ADAM18; ADAM27; Disintegrin and metalloproteinase domain-containing protein 18; MGC41836; MGC88272; tMDC III; TMDC3; tMDCIII; Transmembrane metalloproteinase-like, disintegrin-like, and cysteine-rich protein III
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Gene Symbols: ADAM18
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Molecular weight:
82,856 Da
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Basal Isoelectric point:
7.16
Predict pI for various phosphorylation states
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