|
ADAM18
Sperm surface membrane protein that may be involved in spermatogenesis and fertilization. This is a non catalytic metalloprotease-like protein. Expressed specifically in testis. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
|
| Protein type: Cell adhesion; Membrane protein, integral; Motility/polarity/chemotaxis |
| Chromosomal Location of mouse Ortholog: 8|8 A2 |
|
Cellular Component:
membrane; plasma membrane
|
|
Molecular Function:
integrin binding; metalloendopeptidase activity; metallopeptidase activity
|
|
Biological Process:
binding of sperm to zona pellucida; cell adhesion; cell differentiation; male gonad development; multicellular organism development; proteolysis; spermatogenesis
|
|
Reference #:
Q9R157
(UniProtKB)
|
|
Alt. Names/Synonyms: a disintegrin and metallopeptidase domain 18; ADA18; Adam; ADAM 18; ADAM 27; Adam18; Adam27; disintegrin 3; Disintegrin and metalloproteinase domain-containing protein 18; Disintegrin and metalloproteinase domain-containing protein 27; Dtgn; Dtgn3; OTTMUSP00000030707; tMDC III; Tmdc3; tMDCIII; Transmembrane metalloproteinase-like, disintegrin-like, and cysteine-rich protein III
|
|
Gene Symbols: Adam18
|
|
Molecular weight:
79,210 Da
|
|
Basal Isoelectric point:
5.76
Predict pI for various phosphorylation states
|
