ADAM18 Sperm surface membrane protein that may be involved in spermatogenesis and fertilization. This is a non catalytic metalloprotease-like protein. Expressed specifically in testis. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Cell adhesion; Membrane protein, integral; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 8|8 A2
Cellular Component:  integral component of membrane; membrane
Molecular Function:  integrin binding; metalloendopeptidase activity; metallopeptidase activity
Biological Process:  cell differentiation; multicellular organism development; proteolysis; spermatogenesis
Reference #:  Q9R157 (UniProtKB)
Alt. Names/Synonyms: a disintegrin and metallopeptidase domain 18; ADA18; Adam; ADAM 18; ADAM 27; Adam18; Adam27; disintegrin 3; Disintegrin and metalloproteinase domain-containing protein 18; Disintegrin and metalloproteinase domain-containing protein 27; Dtgn; Dtgn3; OTTMUSP00000030707; tMDC III; Tmdc3; tMDCIII; Transmembrane metalloproteinase-like, disintegrin-like, and cysteine-rich protein III
Gene Symbols: Adam18
Molecular weight: 79,210 Da
Basal Isoelectric point: 5.76  Predict pI for various phosphorylation states
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene