ACTG1 Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells. Belongs to the actin family. Note: This description may include information from UniProtKB.
Protein type: Cytoskeletal; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 17q25.3
Cellular Component:  actin filament; calyx of Held; cytoskeleton; cytosol; dense body; extracellular exosome; filamentous actin; focal adhesion; myofibril; phagocytic vesicle; plasma membrane; postsynaptic actin cytoskeleton; presynaptic actin cytoskeleton; Schaffer collateral - CA1 synapse
Molecular Function:  ATP binding; identical protein binding; profilin binding; protein binding; structural constituent of cytoskeleton; structural constituent of postsynaptic actin cytoskeleton; ubiquitin protein ligase binding
Biological Process:  cell junction assembly; cellular response to interferon-gamma; ephrin receptor signaling pathway; Fc-gamma receptor signaling pathway involved in phagocytosis; membrane organization; postsynaptic actin cytoskeleton organization; response to calcium ion; response to mechanical stimulus; sarcomere organization; synaptic vesicle endocytosis
Disease: Baraitser-winter Syndrome 2; Deafness, Autosomal Dominant 20
Reference #:  P63261 (UniProtKB)
Alt. Names/Synonyms: ACT; ACTB; ACTG; ACTG1; actin gamma 1; Actin, cytoplasmic 2; Actin, cytoplasmic 2, N-terminally processed; actin, gamma 1; cytoskeletal gamma-actin; DFNA20; DFNA26; epididymis luminal protein 176; Gamma-actin; HEL-176
Gene Symbols: ACTG1
Molecular weight: 41,793 Da
Basal Isoelectric point: 5.31  Predict pI for various phosphorylation states
CST Pathways:  Death Receptor Signaling
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein