ZC3H13 Associated component of the WMM complex, a complex that mediates N6-methyladenosine (m6A) methylation of RNAs, a modification that plays a role in the efficiency of mRNA splicing and RNA processing. Acts as a key regulator of m6A methylation by promoting m6A methylation of mRNAs at the 3'-UTR. Controls embryonic stem cells (ESCs) pluripotency via its role in m6A methylation. In the WMM complex, anchors component of the MACOM subcomplex in the nucleus. Also required for bridging WTAP to the RNA-binding component RBM15 (RBM15 or RBM15B). Belongs to the ZC3H13 family. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Unknown function
Chromosomal Location of mouse Ortholog: 14|14 D3
Cellular Component:  nuclear speck; nucleus; RNA N6-methyladenosine methyltransferase complex
Molecular Function:  metal ion binding
Biological Process:  mRNA methylation; mRNA processing; multicellular organism development; regulation of stem cell population maintenance; RNA splicing
Reference #:  E9Q784 (UniProtKB)
Alt. Names/Synonyms: 2600010B19Rik; 3110050K21Rik; 4930570G11Rik; C87618; RIKEN cDNA 3110050K21; Zc3h13; ZC3HD; Zinc finger CCCH domain-containing protein 13; zinc finger CCCH type containing 13
Gene Symbols: Zc3h13
Molecular weight: 203,755 Da
Basal Isoelectric point: 9.41  Predict pI for various phosphorylation states
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Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  BioGPS  |  Pfam  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein