CACNB3 Regulatory subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents. Increases CACNA1B peak calcium current and shifts the voltage dependencies of channel activation and inactivation. Increases CACNA1C peak calcium current and shifts the voltage dependencies of channel activation and inactivation. Belongs to the calcium channel beta subunit family. Expressed mostly in brain, colon and ovary. 5 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Channel, calcium
Chromosomal Location of Human Ortholog: 15 F1|15 54.64 cM
Cellular Component:  apical plasma membrane; cytoplasm; L-type voltage-gated calcium channel complex; membrane; voltage-gated calcium channel complex
Molecular Function:  calcium channel activity; calcium channel regulator activity; high voltage-gated calcium channel activity; protein binding; protein kinase binding; voltage-gated calcium channel activity; voltage-gated ion channel activity
Biological Process:  calcium ion transmembrane transport; calcium ion transmembrane transport via high voltage-gated calcium channel; calcium ion transport; calcium ion transport into cytosol; chemical synaptic transmission; detection of mechanical stimulus involved in sensory perception of pain; ion transport; negative regulation of detection of mechanical stimulus involved in sensory perception of touch; negative regulation of voltage-gated calcium channel activity; neuromuscular junction development; positive regulation of excitatory postsynaptic potential; positive regulation of high voltage-gated calcium channel activity; positive regulation of protein targeting to membrane; positive regulation of voltage-gated calcium channel activity; protein localization to plasma membrane; regulation of ion transmembrane transport; regulation of membrane hyperpolarization; regulation of membrane repolarization during action potential; regulation of voltage-gated calcium channel activity; T cell receptor signaling pathway
Reference #:  P54285 (UniProtKB)
Alt. Names/Synonyms: Beta3; Ca(v)beta3; CAB3; CACB3; Cacnb3; Cacnlb3; calcium channel beta 3 subunit; Calcium channel voltage-dependent subunit beta 3; calcium channel, voltage-dependent, beta 3 subunit; CCHB3; Voltage-dependent L-type calcium channel subunit beta-3
Gene Symbols: Cacnb3
Molecular weight: 54,572 Da
Basal Isoelectric point: 5.86  Predict pI for various phosphorylation states
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CACNB3

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene