GRK4 Specifically phosphorylates the activated forms of G protein-coupled receptors. GRK4-alpha can phosphorylate rhodopsin and its activity is inhibited by calmodulin; the other three isoforms do not phosphorylate rhodopsin and do not interact with calmodulin. GRK4-alpha and GRK4-gamma phosphorylate DRD3. Phosphorylates ADRB2. Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily. Isoform 1, isoform 2, isoform 3, and isoform 4 are expressed in testis. Isoform 4 is expressed in myometrium. 4 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: AGC group; EC; GRK family; GRK subfamily; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor)
Chromosomal Location of human Ortholog: 4p16.3
Cellular Component:  cell cortex; cytoplasm; cytosol; photoreceptor disc membrane; plasma membrane
Molecular Function:  ATP binding; protein kinase activity; rhodopsin kinase activity
Biological Process:  protein phosphorylation; receptor internalization; regulation of G protein-coupled receptor signaling pathway; regulation of rhodopsin mediated signaling pathway; regulation of signal transduction; signal transduction
Reference #:  P32298 (UniProtKB)
Alt. Names/Synonyms: G protein-coupled receptor kinase 2-like; G protein-coupled receptor kinase 4; G protein-coupled receptor kinase GRK4; G-protein coupled receptor kinase 4; GPRK2L; GPRK4; GRK4; GRK4a; IT11; ITI1
Gene Symbols: GRK4
Molecular weight: 66,583 Da
Basal Isoelectric point: 7.93  Predict pI for various phosphorylation states
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Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  KinBase  |  Pfam  |  RCSB PDB  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  InnateDB  |  Ensembl Protein