GRK4
Specifically phosphorylates the activated forms of G protein-coupled receptors. GRK4-alpha can phosphorylate rhodopsin and its activity is inhibited by calmodulin; the other three isoforms do not phosphorylate rhodopsin and do not interact with calmodulin. GRK4-alpha and GRK4-gamma phosphorylate DRD3. Phosphorylates ADRB2. Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily. Isoform 1, isoform 2, isoform 3, and isoform 4 are expressed in testis. Isoform 4 is expressed in myometrium. 4 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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Protein type: AGC group; EC 2.7.11.16; GRK family; GRK subfamily; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) |
Chromosomal Location of human Ortholog: 4p16.3 |
Cellular Component:
cell cortex; cytoplasm; cytosol; photoreceptor disc membrane; plasma membrane
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Molecular Function:
ATP binding; protein kinase activity; rhodopsin kinase activity
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Biological Process:
protein phosphorylation; receptor internalization; regulation of G protein-coupled receptor signaling pathway; regulation of rhodopsin mediated signaling pathway; regulation of signal transduction; signal transduction
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Reference #:
P32298
(UniProtKB)
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Alt. Names/Synonyms: G protein-coupled receptor kinase 2-like; G protein-coupled receptor kinase 4; G protein-coupled receptor kinase GRK4; G-protein coupled receptor kinase 4; GPRK2L; GPRK4; GRK4; GRK4a; IT11; ITI1
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Gene Symbols: GRK4
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Molecular weight:
66,583 Da
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Basal Isoelectric point:
7.93
Predict pI for various phosphorylation states
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