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TDRD3
Scaffolding protein that specifically recognizes and binds dimethylarginine-containing proteins. In nucleus, acts as a coactivator: recognizes and binds asymmetric dimethylation on the core histone tails associated with transcriptional activation (H3R17me2a and H4R3me2a) and recruits proteins at these arginine-methylated loci. In cytoplasm, may play a role in the assembly and/or disassembly of mRNA stress granules and in the regulation of translation of target mRNAs by binding Arg/Gly-rich motifs (GAR) in dimethylarginine-containing proteins. Detected in heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: Histone-binding; RNA-binding; Transcription, coactivator/corepressor; Translation |
| Chromosomal Location of human Ortholog: 13q21.2 |
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Cellular Component:
cytosol; Golgi apparatus; nucleoplasm; nucleus
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Molecular Function:
chromatin binding; methylated histone binding; protein binding; transcription coactivator activity
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Biological Process:
chromatin organization; positive regulation of DNA-templated transcription
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Reference #:
Q9H7E2
(UniProtKB)
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Alt. Names/Synonyms: FLJ21007; TDRD3; tudor domain containing 3; Tudor domain-containing protein 3
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Gene Symbols: TDRD3
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Molecular weight:
73,185 Da
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Basal Isoelectric point:
9.27
Predict pI for various phosphorylation states
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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