TBX3 Transcriptional repressor involved in developmental processes. Probably plays a role in limb pattern formation. Acts as a negative regulator of PML function in cellular senescence. Widely expressed. 4 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: DNA-binding; Transcription factor
Chromosomal Location of Human Ortholog: 5 F|5 60.34 cM
Cellular Component:  nucleus; transcription factor complex
Molecular Function:  DNA binding; DNA-binding transcription factor activity; DNA-binding transcription repressor activity, RNA polymerase II-specific; RNA polymerase II activating transcription factor binding; RNA polymerase II proximal promoter sequence-specific DNA binding; RNA polymerase II transcription factor binding; sequence-specific DNA binding
Biological Process:  animal organ morphogenesis; anterior/posterior axis specification, embryo; atrioventricular bundle cell differentiation; blood vessel development; branching involved in mammary gland duct morphogenesis; cardiac muscle cell differentiation; cardiac muscle cell fate commitment; cell aging; cellular senescence; embryonic digit morphogenesis; embryonic forelimb morphogenesis; embryonic heart tube development; embryonic hindlimb morphogenesis; female genitalia development; follicle-stimulating hormone secretion; forelimb morphogenesis; heart looping; heart morphogenesis; in utero embryonic development; limb morphogenesis; limbic system development; luteinizing hormone secretion; male genitalia development; mammary gland development; mammary placode formation; mesoderm morphogenesis; multicellular organism development; negative regulation of apoptotic process; negative regulation of epithelial cell differentiation; negative regulation of myoblast differentiation; negative regulation of transcription by RNA polymerase II; negative regulation of transcription, DNA-templated; outflow tract morphogenesis; positive regulation of cell cycle; positive regulation of cell proliferation; positive regulation of stem cell proliferation; positive regulation of transcription, DNA-templated; regulation of cell proliferation; regulation of transcription, DNA-templated; roof of mouth development; sinoatrial node cell development; skeletal system development; specification of animal organ position; stem cell population maintenance; ventricular septum morphogenesis
Reference #:  P70324 (UniProtKB)
Alt. Names/Synonyms: D5Ertd189; D5Ertd189e; T-box 3; T-box protein 3; T-box transcription factor TBX3; Tbx3
Gene Symbols: Tbx3
Molecular weight: 79,160 Da
Basal Isoelectric point: 8.05  Predict pI for various phosphorylation states
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene