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TBX2
Involved in the transcriptional regulation of genes required for mesoderm differentiation. Probably plays a role in limb pattern formation. Acts as a negative regulator of PML function in cellular senescence. May be required for cardiac atrioventricular canal formation. Expressed primarily in adult in kidney, lung, and placenta. Weak expression in heart and ovary. Note: This description may include information from UniProtKB.
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| Protein type: DNA-binding; Transcription factor |
| Chromosomal Location of Human Ortholog: 11 C|11 51.34 cM |
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Cellular Component:
nucleus; transcription factor complex
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Molecular Function:
DNA binding; DNA-binding transcription factor activity; DNA-binding transcription repressor activity, RNA polymerase II-specific; protein binding; RNA polymerase II proximal promoter sequence-specific DNA binding; sequence-specific DNA binding
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Biological Process:
aorta morphogenesis; atrioventricular canal development; cardiac muscle tissue development; cell aging; cellular senescence; developmental growth involved in morphogenesis; embryonic camera-type eye morphogenesis; embryonic digit morphogenesis; endocardial cushion morphogenesis; heart morphogenesis; mammary placode formation; multicellular organism development; muscle cell fate determination; negative regulation of cardiac chamber formation; negative regulation of heart looping; negative regulation of transcription by RNA polymerase II; negative regulation of transcription, DNA-templated; Notch signaling pathway; outflow tract morphogenesis; outflow tract septum morphogenesis; pharynx development; positive regulation of cardiac muscle cell proliferation; positive regulation of cell proliferation; regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiation; regulation of transcription, DNA-templated; roof of mouth development
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Reference #:
Q60707
(UniProtKB)
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Alt. Names/Synonyms: OTTMUSP00000000995; T-box 2; T-box protein 2; T-box transcription factor TBX2; Tbx2
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Gene Symbols: Tbx2
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Molecular weight:
75,081 Da
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Basal Isoelectric point:
9.2
Predict pI for various phosphorylation states
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