Fused Serine/threonine protein kinase which plays an important role in the sonic hedgehog (Shh) pathway by regulating the activity of GLI transcription factors. Controls the activity of the transcriptional regulators GLI1, GLI2 and GLI3 by opposing the effect of SUFU and promoting their nuclear localization. GLI2 requires an additional function of STK36 to become transcriptionally active, but the enzyme does not need to possess an active kinase catalytic site for this to occur. Required for postnatal development, possibly by regulating the homeostasis of cerebral spinal fluid or ciliary function. Essential for construction of the central pair apparatus of motile cilia. Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. Expressed at low levels in most fetal tissues, adult ovaries and at high levels in adult testis, where it is localized in germ cells. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: EC; Kinase, protein; Other group; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor); ULK family
Chromosomal Location of human Ortholog: 2q35
Cellular Component:  cytoplasm; cytosol; nucleus
Molecular Function:  ATP binding; metal ion binding; protein binding; protein serine/threonine kinase activity; transcription factor binding
Biological Process:  brain development; cilium assembly; epithelial cilium movement; positive regulation of hh target transcription factor activity; positive regulation of smoothened signaling pathway; post-embryonic development; protein phosphorylation; regulation of DNA-binding transcription factor activity
Disease: Ciliary Dyskinesia, Primary, 46
Reference #:  Q9NRP7 (UniProtKB)
Alt. Names/Synonyms: DKFZp434N0223; FU; Fused; Fused homolog; KIAA1278; serine/threonine kinase 36; serine/threonine kinase 36, fused homolog (Drosophila); Serine/threonine-protein kinase 36; STK36; testicular tissue protein Li 188
Gene Symbols: STK36
Molecular weight: 143,995 Da
Basal Isoelectric point: 5.57  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  KinBase  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein