Fused a serine/threonine protein kinase of the ULK family. Plays a role in Hedgehog (Hh) signaling. Interacts with Smoothened (Smo), the receptor for Hedgehog (Hh). Required for postnatal development, possibly by regulating the homeostasis of cerebral spinal fluid or ciliary function. Controls the activity of the transcriptional regulators GLI1, GLI2 and GLI3 by opposing the effect of SUFU and promoting their nuclear localization. GLI2 requires an additional function of Fused to become transcriptionally active, but the enzyme does not need to possess an active kinase catalytic site for this to occur. Two alternatively spliced isoforms have been described. Note: This description may include information from UniProtKB.
Protein type: EC; Kinase, protein; Other group; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor); ULK family
Chromosomal Location of Human Ortholog: 2q35
Cellular Component:  cytoplasm; cytosol; nucleus
Molecular Function:  ATP binding; metal ion binding; protein binding; protein serine/threonine kinase activity; transcription factor binding
Biological Process:  brain development; cilium assembly; epithelial cilium movement; positive regulation of hh target transcription factor activity; positive regulation of smoothened signaling pathway; post-embryonic development; protein phosphorylation; regulation of DNA-binding transcription factor activity
Reference #:  Q9NRP7 (UniProtKB)
Alt. Names/Synonyms: DKFZp434N0223; FU; Fused homolog; KIAA1278; serine/threonine kinase 36, fused homolog (Drosophila); Serine/threonine-protein kinase 36; STK36
Gene Symbols: STK36
Molecular weight: 143,995 Da
Basal Isoelectric point: 5.57  Predict pI for various phosphorylation states
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Protein Structure Not Found.

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