SSA2 RNA-binding protein that binds to misfolded non-coding RNAs, pre-5S rRNA, and several small cytoplasmic RNA molecules known as Y RNAs. May stabilize some of these RNAs and protect them from degradation. Binds to endogenous Alu retroelements which are induced by type I interferon and stimulate porinflammaotry cytokine secretion. Regulates the expression of Alu retroelements as well as inflammatory genes. May play roles in cilia formation and/or maintenance. Belongs to the Ro 60 kDa family. 5 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: RNA-binding
Chromosomal Location of human Ortholog: 1q31.2
Cellular Component:  cytosol; nucleoplasm; ribonucleoprotein complex
Molecular Function:  metal ion binding; RNA binding; U2 snRNA binding
Biological Process:  cellular response to interferon-alpha; cilium assembly; immune system development; regulation of gene expression; response to UV; smoothened signaling pathway; transcription by RNA polymerase III
Disease: Heart Block, Congenital
Reference #:  P10155 (UniProtKB)
Alt. Names/Synonyms: 60 kDa ribonucleoprotein Ro; 60 kDa Ro protein; 60 kDa SS-A/Ro ribonucleoprotein; gastric cancer multi-drug resistance protein; Ro 60 kDa autoantigen; Ro/SSA 60kDa; RO60; Ro60 autoantigen; Ro60, Y RNA binding protein; RoRNP; Sjoegren syndrome antigen A2; Sjoegren syndrome type A antigen; Sjogren syndrome antigen A2 (60kD, ribonucleoprotein autoantigen SS-A/Ro); SS-A; SSA2; TROVE domain family member 2; TROVE domain family, member 2; TROVE2
Gene Symbols: RO60
Molecular weight: 60,671 Da
Basal Isoelectric point: 8.27  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein