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SSA2
RNA-binding protein that binds to misfolded non-coding RNAs, pre-5S rRNA, and several small cytoplasmic RNA molecules known as Y RNAs. May stabilize some of these RNAs and protect them from degradation. Binds to endogenous Alu retroelements which are induced by type I interferon and stimulate porinflammaotry cytokine secretion. Regulates the expression of Alu retroelements as well as inflammatory genes. May play roles in cilia formation and/or maintenance. Belongs to the Ro 60 kDa family. 5 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: RNA-binding |
| Chromosomal Location of human Ortholog: 1q31.2 |
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Cellular Component:
cytosol; nuclear body; nucleoplasm; ribonucleoprotein complex
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Molecular Function:
metal ion binding; RNA binding; U2 snRNA binding
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Biological Process:
cellular response to interferon-alpha; cilium assembly; immune system development; regulation of gene expression; response to UV; smoothened signaling pathway; transcription by RNA polymerase III
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Disease: Heart Block, Congenital
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Reference #:
P10155
(UniProtKB)
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Alt. Names/Synonyms: 60 kDa ribonucleoprotein Ro; 60 kDa Ro protein; 60 kDa SS-A/Ro ribonucleoprotein; gastric cancer multi-drug resistance protein; RNA-binding protein RO60; Ro 60 kDa autoantigen; Ro/SSA 60kDa; RO60; Ro60 autoantigen; Ro60, Y RNA binding protein; RoRNP; Sjoegren syndrome antigen A2; Sjoegren syndrome type A antigen; Sjogren syndrome antigen A2 (60kD, ribonucleoprotein autoantigen SS-A/Ro); SS-A; SSA2; TROVE domain family member 2; TROVE domain family, member 2; TROVE2
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Gene Symbols: RO60
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Molecular weight:
60,671 Da
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Basal Isoelectric point:
8.27
Predict pI for various phosphorylation states
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