PRMT1 Arginine methyltransferase that methylates (mono and asymmetric dimethylation) the guanidino nitrogens of arginyl residues present in proteins such as ESR1, histone H2, H3 and H4, PIAS1, HNRNPA1, HNRNPD, NFATC2IP, SUPT5H, TAF15 and EWS. Constitutes the main enzyme that mediates monomethylation and asymmetric dimethylation of histone H4 'Arg-4' (H4R3me1 and H4R3me2a, respectively), a specific tag for epigenetic transcriptional activation. Together with dimethylated PIAS1, represses STAT1 transcriptional activity, in the late phase of interferon gamma (IFN-gamma) signaling. May be involved in the regulation of TAF15 transcriptional activity, act as an activator of estrogen receptor (ER)-mediated transactivation, play a key role in neurite outgrowth and act as a negative regulator of megakaryocytic differentiation, by modulating p38 MAPK pathway. Homodimer and heterodimer with PRMT8. The dimer can then associate to form a homohexamer. Interacts with ILF3, BTG1, BTG2, SUPT5H and interferon-alpha/beta receptor 1. Interacts with NFATC2IP. Widely expressed. By BTG1, BTG2 and ILF3. Belongs to the protein arginine N-methyltransferase family. 3 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: EC 2.1.1.125; Methyltransferase; Methyltransferase, protein arginine; Nuclear receptor co-regulator
Chromosomal Location of Human Ortholog: 7 B3|7 29.07 cM
Cellular Component:  cytoplasm; cytosol; membrane; methylosome; nucleoplasm; nucleus; protein-containing complex
Molecular Function:  [cytochrome c]-arginine N-methyltransferase activity; enzyme binding; histone methyltransferase activity; histone methyltransferase activity (H4-R3 specific); histone-arginine N-methyltransferase activity; identical protein binding; methyl-CpG binding; methyltransferase activity; mitogen-activated protein kinase p38 binding; N-methyltransferase activity; protein binding; protein methyltransferase activity; protein-arginine N-methyltransferase activity; protein-arginine omega-N asymmetric methyltransferase activity; protein-arginine omega-N monomethyltransferase activity; S-adenosyl-L-methionine binding; snoRNP binding; transferase activity
Biological Process:  histone arginine methylation; histone H4-R3 methylation; histone methylation; in utero embryonic development; methylation; negative regulation of megakaryocyte differentiation; neuron projection development; peptidyl-arginine methylation; peptidyl-arginine methylation, to asymmetrical-dimethyl arginine; peptidyl-arginine omega-N-methylation; positive regulation of cell proliferation; positive regulation of erythrocyte differentiation; positive regulation of hemoglobin biosynthetic process; positive regulation of p38MAPK cascade; protein homooligomerization; protein methylation; regulation of megakaryocyte differentiation; regulation of transcription, DNA-templated
Reference #:  Q9JIF0 (UniProtKB)
Alt. Names/Synonyms: 6720434D09Rik; ANM1; arginine N-methyltransferase 1; AW214366; heterogeneous nuclear ribonucleoproteins methyltransferase-like 2; Hrmt1l2; Mrmt1; OTTMUSP00000022387; Prmt1; Protein arginine N-methyltransferase 1
Gene Symbols: Prmt1
Molecular weight: 42,436 Da
Basal Isoelectric point: 5.24  Predict pI for various phosphorylation states
CST Pathways:  Histone Methylation
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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PRMT1

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  BioGPS  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene  |  NURSA