PEX14 Peroxisome membrane protein that is an essential component of the peroxisomal import machinery. Functions as a docking factor for the predominantly cytoplasmic PTS1 receptor (PEX5). Plays a key role for peroxisome movement through a direct interaction with tubulin. Belongs to the peroxin-14 family. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Adaptor/scaffold
Chromosomal Location of Human Ortholog: 4|4 E2
Cellular Component:  fibrillar center; integral component of membrane; membrane; peroxisomal importomer complex; peroxisomal membrane; peroxisome; protein-containing complex
Molecular Function:  beta-tubulin binding; microtubule binding; protein N-terminus binding; signaling receptor binding; transcription corepressor activity
Biological Process:  microtubule anchoring; negative regulation of DNA-binding transcription factor activity; negative regulation of protein binding; negative regulation of protein homotetramerization; negative regulation of transcription, DNA-templated; peroxisome organization; peroxisome transport along microtubule; protein homooligomerization; protein import into peroxisome matrix; protein import into peroxisome matrix, docking; protein import into peroxisome matrix, substrate release; protein import into peroxisome matrix, translocation; protein transport; protein-containing complex assembly
Reference #:  Q9R0A0 (UniProtKB)
Alt. Names/Synonyms: OTTMUSP00000011762; Peroxin-14; peroxisomal biogenesis factor 14; Peroxisomal membrane anchor protein PEX14; Peroxisomal membrane protein PEX14; peroxisomal protein Pex14; Pex14; Pex14p; PTS1 receptor-docking protein; R75137
Gene Symbols: Pex14
Molecular weight: 41,208 Da
Basal Isoelectric point: 5.03  Predict pI for various phosphorylation states
Select Structure to View Below

PEX14

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein