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PEX14
Peroxisome membrane protein that is an essential component of the peroxisomal import machinery. Functions as a docking factor for the predominantly cytoplasmic PTS1 receptor (PEX5). Plays a key role for peroxisome movement through a direct interaction with tubulin. Belongs to the peroxin-14 family. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: Adaptor/scaffold |
| Chromosomal Location of mouse Ortholog: 4|4 E2 |
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Cellular Component:
fibrillar center; membrane; peroxisomal importomer complex; peroxisomal membrane; peroxisome; protein-containing complex
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Molecular Function:
beta-tubulin binding; identical protein binding; microtubule binding; protein transmembrane transporter activity; protein-macromolecule adaptor activity; signaling receptor binding; transcription corepressor activity
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Biological Process:
cellular response to reactive oxygen species; microtubule anchoring; negative regulation of DNA-binding transcription factor activity; negative regulation of DNA-templated transcription; negative regulation of protein binding; peroxisome organization; peroxisome transport along microtubule; protein import into peroxisome matrix; protein import into peroxisome matrix, docking; protein import into peroxisome matrix, substrate release; protein import into peroxisome matrix, translocation; protein transport; protein-containing complex assembly
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Reference #:
Q9R0A0
(UniProtKB)
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Alt. Names/Synonyms: OTTMUSP00000011762; Peroxin-14; peroxisomal biogenesis factor 14; Peroxisomal membrane anchor protein PEX14; Peroxisomal membrane protein PEX14; peroxisomal protein Pex14; Pex1; Pex14; Pex14p; PTS1 receptor-docking protein; R75137
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Gene Symbols: Pex14
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Molecular weight:
41,208 Da
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Basal Isoelectric point:
5.03
Predict pI for various phosphorylation states
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