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PEX14
Peroxisome membrane protein that is an essential component of the peroxisomal import machinery. Functions as a docking factor for the predominantly cytoplasmic PTS1 receptor (PEX5). Plays a key role for peroxisome movement through a direct interaction with tubulin. Belongs to the peroxin-14 family. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: Adaptor/scaffold |
| Chromosomal Location of human Ortholog: 1p36.22 |
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Cellular Component:
cytosol; fibrillar center; membrane; nucleus; peroxisomal importomer complex; peroxisomal membrane; peroxisome; protein-containing complex
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Molecular Function:
beta-tubulin binding; identical protein binding; microtubule binding; protein binding; protein transmembrane transporter activity; protein-macromolecule adaptor activity; signaling receptor binding; transcription corepressor activity
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Biological Process:
cellular response to reactive oxygen species; microtubule anchoring; negative regulation of DNA-binding transcription factor activity; negative regulation of DNA-templated transcription; negative regulation of protein binding; peroxisome organization; peroxisome transport along microtubule; protein import into peroxisome matrix; protein import into peroxisome matrix, docking; protein import into peroxisome matrix, substrate release; protein import into peroxisome matrix, translocation; protein-containing complex assembly
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Disease: Peroxisome Biogenesis Disorder 13a (zellweger)
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Reference #:
O75381
(UniProtKB)
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Alt. Names/Synonyms: dJ734G22.2; MGC12767; NAPP2; NF-E2 associated polypeptide 2; PBD13A; Peroxin-14; peroxisomal biogenesis factor 14; Peroxisomal membrane anchor protein PEX14; peroxisomal membrane anchor protein Pex14p; Peroxisomal membrane protein PEX14; PEX14; Pex14p; PTS1 receptor docking protein; PTS1 receptor-docking protein
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Gene Symbols: PEX14
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Molecular weight:
41,237 Da
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Basal Isoelectric point:
4.89
Predict pI for various phosphorylation states
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