MYST3 Histone acetyltransferase that acetylates lysine residues in histone H3 and histone H4 (in vitro). Component of the MOZ/MORF complex which has a histone H3 acetyltransferase activity. May act as a transcriptional coactivator for RUNX1 and RUNX2. Acetylates p53/TP53 at 'Lys-120' and 'Lys-382' and controls its transcriptional activity via association with PML. Belongs to the MYST (SAS/MOZ) family. Note: This description may include information from UniProtKB.
Protein type: Acetyltransferase; EC 2.3.1.48; Nucleolus; Oncoprotein
Chromosomal Location of Human Ortholog: 8p11.21
Cellular Component:  cytosol; MOZ/MORF histone acetyltransferase complex; nuclear speck; nucleolus; nucleoplasm; nucleosome; nucleus; PML body
Molecular Function:  acetyltransferase activity; DNA binding; histone acetyltransferase activity; protein binding; transcription coactivator activity; transcription factor binding; zinc ion binding
Biological Process:  cellular senescence; DNA packaging; histone acetylation; histone H3 acetylation; histone H4 acetylation; myeloid cell differentiation; negative regulation of transcription, DNA-templated; nucleosome assembly; positive regulation of transcription, DNA-templated; protein acetylation; regulation of signal transduction by p53 class mediator
Disease: Mental Retardation, Autosomal Dominant 32
Reference #:  Q92794 (UniProtKB)
Alt. Names/Synonyms: Histone acetyltransferase KAT6A; Histone acetyltransferase MYST3; KAT6A; MGC167033; Monocytic leukemia zinc finger protein; MOZ; MOZ, YBF2/SAS3, SAS2 and TIP60 protein 3; MYST histone acetyltransferase (monocytic leukemia) 3; MYST-3; MYST3; runt-related transcription factor binding protein 2; Runt-related transcription factor-binding protein 2; RUNXBP2; Zinc finger protein 220; ZNF220
Gene Symbols: KAT6A
Molecular weight: 225,028 Da
Basal Isoelectric point: 5.5  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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MYST3

Protein Structure Not Found.


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