MTMR6 Phosphatase that acts on lipids with a phosphoinositol headgroup. Dephosphorylates phosphatidylinositol 3-phosphate (PtdIns(3)P) and phosphatidylinositol 3,5-bisphosphate. Binds with high affinity to phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2) but also to phosphatidylinositol 3-phosphate (PtdIns(3)P), phosphatidylinositol 4-phosphate (PtdIns(4)P), and phosphatidylinositol 5-phosphate (PtdIns(5)P), phosphatidic acid and phosphatidylserine. Negatively regulates ER-Golgi protein transport. Probably in association with MTMR9, plays a role in the late stages of macropinocytosis by dephosphorylating phosphatidylinositol 3-phosphate in membrane ruffles. Acts as a negative regulator of KCNN4/KCa3.1 channel activity in CD4(+) T-cells possibly by decreasing intracellular levels of phosphatidylinositol 3-phosphate. Negatively regulates proliferation of reactivated CD4(+) T-cells. In complex with MTMR9, negatively regulates DNA damage-induced apoptosis. The formation of the MTMR6-MTMR9 complex stabilizes both MTMR6 and MTMR9 protein levels. Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily. Expressed in CD4+ T-cells. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Carbohydrate Metabolism - fructose and mannose; Cofactor and Vitamin Metabolism - riboflavin; Cofactor and Vitamin Metabolism - thiamine; EC 3.1.3.-; Phosphatase, lipid; Protein phosphatase, tyrosine (non-receptor)
Chromosomal Location of Human Ortholog: 13q12.13
Cellular Component:  cytoplasm; cytosol; endoplasmic reticulum; endoplasmic reticulum-Golgi intermediate compartment; nuclear envelope; perinuclear region of cytoplasm; ruffle membrane
Molecular Function:  calcium-activated potassium channel activity; phosphatidylinositol-3,5-bisphosphate phosphatase activity; phosphatidylinositol-3-phosphatase activity; protein binding; protein serine/threonine phosphatase activity; protein tyrosine phosphatase activity
Biological Process:  endocytosis; peptidyl-tyrosine dephosphorylation; phosphatidylinositol biosynthetic process; phosphatidylinositol dephosphorylation; potassium ion transmembrane transport; protein dephosphorylation
Reference #:  Q9Y217 (UniProtKB)
Alt. Names/Synonyms: MTMR6; myotubularin related protein 6; Myotubularin-related protein 6; Phosphatidylinositol-3,5-bisphosphate 3-phosphatase; Phosphatidylinositol-3-phosphate phosphatase
Gene Symbols: MTMR6
Molecular weight: 71,968 Da
Basal Isoelectric point: 7.59  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  InnateDB