MRGBP Component of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. NuA4 may also play a direct role in DNA repair when recruited to sites of DNA damage. Belongs to the EAF7 family. Note: This description may include information from UniProtKB.
Protein type: Acetyltransferase
Chromosomal Location of human Ortholog: 20q13.33
Cellular Component:  NuA4 histone acetyltransferase complex; nucleoplasm; nucleosome
Molecular Function:  protein binding
Biological Process:  chromatin organization; histone acetylation; histone H2A acetylation; histone H4 acetylation; positive regulation of DNA-templated transcription; positive regulation of double-strand break repair via homologous recombination; regulation of apoptotic process; regulation of cell cycle; regulation of double-strand break repair; regulation of transcription by RNA polymerase II
Reference #:  Q9NV56 (UniProtKB)
Alt. Names/Synonyms: C20orf20; chromosome 20 open reading frame 20; Eaf7; FLJ10914; MRG domain binding protein; MRG(MORF4-related gene)-binding protein; MRG-binding protein; MRG/MORF4L binding protein; MRG/MORF4L-binding protein; MRG15BP; MRGBP; Up-regulated in colon cancer 4; URCC4
Gene Symbols: MRGBP
Molecular weight: 22,417 Da
Basal Isoelectric point: 5.57  Predict pI for various phosphorylation states
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Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein