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MRGBP
Component of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. NuA4 may also play a direct role in DNA repair when recruited to sites of DNA damage. Belongs to the EAF7 family. Note: This description may include information from UniProtKB.
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| Protein type: Acetyltransferase |
| Chromosomal Location of Human Ortholog: 20q13.33 |
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Cellular Component:
nucleoplasm; nucleus
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Molecular Function:
protein binding
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Biological Process:
regulation of growth
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Reference #:
Q9NV56
(UniProtKB)
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Alt. Names/Synonyms: C20orf20; chromosome 20 open reading frame 20; Eaf7; FLJ10914; MRG domain binding protein; MRG(MORF4-related gene)-binding protein; MRG-binding protein; MRG/MORF4L binding protein; MRG/MORF4L-binding protein; MRG15BP; MRGBP; Up-regulated in colon cancer 4; URCC4
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Gene Symbols: MRGBP
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Molecular weight:
22,417 Da
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Basal Isoelectric point:
5.57
Predict pI for various phosphorylation states
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