LXR-beta Nuclear receptor that exhibits a ligand-dependent transcriptional activation activity. Binds preferentially to double-stranded oligonucleotide direct repeats having the consensus half-site sequence 5'-AGGTCA-3' and 4-nt spacing (DR-4). Regulates cholesterol uptake through MYLIP-dependent ubiquitination of LDLR, VLDLR and LRP8; DLDLR and LRP8. Interplays functionally with RORA for the regulation of genes involved in liver metabolism. Plays an anti-inflammatory role during the hepatic acute phase response by acting as a corepressor: inhibits the hepatic acute phase response by preventing dissociation of the N-Cor corepressor complex. Belongs to the nuclear hormone receptor family. NR1 subfamily. Ubiquitous. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Nuclear receptor
Chromosomal Location of Human Ortholog: 19q13.33
Cellular Component:  cytoplasm; nucleoplasm; nucleus
Molecular Function:  apolipoprotein A-I receptor binding; ATPase binding; DNA binding; DNA-binding transcription activator activity, RNA polymerase II-specific; DNA-binding transcription factor activity, RNA polymerase II-specific; nuclear receptor activity; protein binding; RNA polymerase II proximal promoter sequence-specific DNA binding; steroid hormone receptor activity; zinc ion binding
Biological Process:  cholesterol homeostasis; intracellular receptor signaling pathway; negative regulation of cholesterol storage; negative regulation of cold-induced thermogenesis; negative regulation of interferon-gamma-mediated signaling pathway; negative regulation of lipid transport; negative regulation of macrophage derived foam cell differentiation; negative regulation of pinocytosis; negative regulation of transcription, DNA-templated; positive regulation of cellular protein metabolic process; positive regulation of cholesterol efflux; positive regulation of cholesterol transport; positive regulation of fatty acid biosynthetic process; positive regulation of lipoprotein lipase activity; positive regulation of transcription by RNA polymerase II; positive regulation of transcription, DNA-templated; positive regulation of triglyceride biosynthetic process; steroid hormone mediated signaling pathway; transcription initiation from RNA polymerase II promoter
Reference #:  P55055 (UniProtKB)
Alt. Names/Synonyms: Liver X receptor beta; liver X receptor-beta; LX receptor beta; LXR-b; LXRB; NER; NER-I; NR1H2; nuclear orphan receptor LXR-beta; Nuclear receptor NER; Nuclear receptor subfamily 1 group H member 2; nuclear receptor subfamily 1, group H, member 2; Oxysterols receptor LXR-beta; RIP15; steroid hormone-nuclear receptor NER; Ubiquitously-expressed nuclear receptor; UNR
Gene Symbols: NR1H2
Molecular weight: 50,974 Da
Basal Isoelectric point: 7.9  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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LXR-beta

Protein Structure Not Found.


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