IARS Catalyzes the specific attachment of an amino acid to its cognate tRNA in a 2 step reaction: the amino acid (AA) is first activated by ATP to form AA-AMP and then transferred to the acceptor end of the tRNA. Belongs to the class-I aminoacyl-tRNA synthetase family. Expressed in liver and muscle (at protein level). Note: This description may include information from UniProtKB.
Protein type: Amino Acid Metabolism - valine, leucine and isoleucine biosynthesis; Aminoacyl-tRNA synthetase; EC; Ligase; Translation; Translation regulation
Chromosomal Location of Human Ortholog: 9q22.31
Cellular Component:  aminoacyl-tRNA synthetase multienzyme complex; cytoplasm; cytosol
Molecular Function:  aminoacyl-tRNA editing activity; ATP binding; GTPase binding; isoleucine-tRNA ligase activity; protein binding; tRNA binding
Biological Process:  aminoacyl-tRNA metabolism involved in translational fidelity; isoleucyl-tRNA aminoacylation; tRNA aminoacylation for protein translation
Disease: Growth Retardation, Intellectual Developmental Disorder, Hypotonia, And Hepatopathy
Reference #:  P41252 (UniProtKB)
Alt. Names/Synonyms: FLJ20736; GRIDHH; IARS; IARS1; IleRS; ILRS; IRS; isoleucine tRNA ligase 1, cytoplasmic; Isoleucine--tRNA ligase; Isoleucine--tRNA ligase, cytoplasmic; isoleucyl-tRNA synthetase; isoleucyl-tRNA synthetase 1; Isoleucyl-tRNA synthetase, cytoplasmic; PRO0785; SYIC
Gene Symbols: IARS1
Molecular weight: 144,498 Da
Basal Isoelectric point: 5.82  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein