HMGB1 DNA binding proteins that associates with chromatin and has the ability to bend DNA. Binds preferentially single-stranded DNA. Involved in V(D)J recombination by acting as a cofactor of the RAG complex. Acts by stimulating cleavage and RAG protein binding at the 23 bp spacer of conserved recombination signal sequences (RSS). Heparin-binding protein that has a role in the extension of neurite-type cytoplasmic processes in developing cells. Component of the RAG complex composed of core components RAG1 and RAG2, and associated component HMGB1 or HMGB2. Belongs to the HMGB family. Note: This description may include information from UniProtKB.
Protein type: DNA repair, damage; Nuclear receptor co-regulator
Chromosomal Location of Human Ortholog: 5 G3|5 89.18 cM
Cellular Component:  cytoplasm; early endosome; extracellular region; extracellular space; neuron projection; nuclear chromatin; nucleus
Molecular Function:  bent DNA binding; calcium-dependent protein kinase regulator activity; crossed form four-way junction DNA binding; cytokine activity; DNA binding, bending; double-stranded DNA binding; double-stranded RNA binding; open form four-way junction DNA binding; phosphatidylserine binding; protein binding; protein kinase activator activity; single-stranded RNA binding; transcription factor binding
Biological Process:  activation of innate immune response; base-excision repair; cell chemotaxis; cellular response to interleukin-7; cellular response to lipopolysaccharide; chromatin assembly; chromatin remodeling; developmental process; DNA geometric change; DNA recombination; endothelial cell chemotaxis; endothelial cell proliferation; eye development; induction of positive chemotaxis; inflammatory response; lung development; macrophage activation involved in immune response; myeloid dendritic cell activation; plasmacytoid dendritic cell activation; positive regulation of autophagy; positive regulation of cell migration; positive regulation of ERK1 and ERK2 cascade; positive regulation of glycogen catabolic process; positive regulation of innate immune response; positive regulation of interferon-alpha production; positive regulation of interferon-alpha secretion; positive regulation of interferon-beta production; positive regulation of interleukin-1 beta secretion; positive regulation of interleukin-1 secretion; positive regulation of interleukin-6 production; positive regulation of mesenchymal cell proliferation; positive regulation of mitotic cell cycle; positive regulation of monocyte chemotactic protein-1 production; positive regulation of myeloid cell differentiation; positive regulation of NIK/NF-kappaB signaling; positive regulation of protein phosphorylation; positive regulation of sprouting angiogenesis; positive regulation of toll-like receptor 2 signaling pathway; positive regulation of toll-like receptor 4 signaling pathway; positive regulation of transcription by RNA polymerase II; positive regulation of tumor necrosis factor production; positive regulation of wound healing; regulation of autophagy; regulation of nucleotide-excision repair; regulation of signaling receptor activity; regulation of T cell mediated immune response to tumor cell; regulation of tolerance induction; regulation of transcription by RNA polymerase II; response to glucocorticoid
Reference #:  P63158 (UniProtKB)
Alt. Names/Synonyms: amphoterin; DEF; high mobility group box 1; High mobility group protein 1; High mobility group protein B1; HMG-1; Hmg1; Hmgb1; MGC103168; MGC103169; MGC117896; MGC117897; OTTMUSP00000018031; OTTMUSP00000018032; OTTMUSP00000018033; p30; SBP-1
Gene Symbols: Hmgb1
Molecular weight: 24,894 Da
Basal Isoelectric point: 5.62  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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HMGB1

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene  |  NURSA