HINT1 Hydrolyzes purine nucleotide phosphoramidates with a single phosphate group, including adenosine 5'monophosphoramidate (AMP-NH2), adenosine 5'monophosphomorpholidate (AMP-morpholidate) and guanosine 5'monophosphomorpholidate (GMP-morpholidate). Hydrolyzes lysyl-AMP (AMP-N-epsilon-(N-alpha-acetyl lysine methyl ester)) generated by lysine tRNA ligase, as well as Met-AMP, His-AMP and Asp-AMP, lysyl-GMP (GMP-N-epsilon-(N-alpha-acetyl lysine methyl ester)) and AMP-N-alanine methyl ester. Can also convert adenosine 5'-O-phosphorothioate and guanosine 5'-O-phosphorothioate to the corresponding nucleoside 5'-O-phosphates with concomitant release of hydrogen sulfide. In addition, functions as scaffolding protein that modulates transcriptional activation by the LEF1/TCF1-CTNNB1 complex and by the complex formed with MITF and CTNNB1. Modulates p53/TP53 levels and p53/TP53-mediated apoptosis. Modulates proteasomal degradation of target proteins by the SCF (SKP2-CUL1-F-box protein) E3 ubiquitin-protein ligase complex. Belongs to the HINT family. Widely expressed. Note: This description may include information from UniProtKB.
Protein type: Cytoskeletal; EC 3.-.-.-; Hydrolase
Chromosomal Location of mouse Ortholog: 11|11 B1.3
Cellular Component:  cytoplasm; cytosol; histone deacetylase complex; nucleus; plasma membrane
Molecular Function:  catalytic activity; hydrolase activity; nucleotide binding
Biological Process:  apoptotic process; intrinsic apoptotic signaling pathway by p53 class mediator; positive regulation of calcium-mediated signaling; purine ribonucleotide catabolic process; regulation of transcription, DNA-templated
Reference #:  P70349 (UniProtKB)
Alt. Names/Synonyms: AA673479; Adenosine 5'-monophosphoramidase; Hint; Hint1; histidine triad nucleotide binding protein 1; Histidine triad nucleotide-binding protein 1; Ipk1; OTTMUSP00000005856; PKC inhibitor/ interacting protein; Pkci; PKCI-1; Pkci1; PRKC; Prkcnh1; Protein kinase C inhibitor 1; Protein kinase C-interacting protein 1
Gene Symbols: Hint1
Molecular weight: 13,777 Da
Basal Isoelectric point: 6.36  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  BioGPS  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene