DYRK2 a dual-specificity protein kinase of the DYRK family. Localizes in the cytoplasm. Phosphorylates the translation initiation factor eIF2B at Ser539, priming it for phosphorylation by glycogen synthase kinase-3. Note: This description may include information from UniProtKB.
Protein type: CMGC group; DYRK family; Dyrk2 subfamily; EC; Kinase, protein; Protein kinase, CMGC; Protein kinase, dual-specificity (non-receptor)
Chromosomal Location of Human Ortholog: 12q15
Cellular Component:  cytoplasm; cytosol; nucleoplasm; nucleus; ribonucleoprotein complex; ubiquitin ligase complex
Molecular Function:  ATP binding; magnesium ion binding; manganese ion binding; protein binding; protein serine/threonine kinase activity; protein serine/threonine/tyrosine kinase activity; protein tyrosine kinase activity
Biological Process:  cellular response to DNA damage stimulus; intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator; negative regulation of calcineurin-NFAT signaling cascade; peptidyl-tyrosine phosphorylation; positive regulation of glycogen biosynthetic process; protein phosphorylation; regulation of signal transduction by p53 class mediator; smoothened signaling pathway
Reference #:  Q92630 (UniProtKB)
Alt. Names/Synonyms: Dual specificity tyrosine-phosphorylation-regulated kinase 2; dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 2; DYRK2; FLJ21217; FLJ21365
Gene Symbols: DYRK2
Molecular weight: 66,652 Da
Basal Isoelectric point: 9.7  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below


Protein Structure Not Found.

Substrate Sequence Logo
Open Substrate Page

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  KinBase  |  Pfam  |  RCSB PDB  |  ENZYME  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein