GRP94 Molecular chaperone that functions in the processing and transport of secreted proteins. When associated with CNPY3, required for proper folding of Toll-like receptors. Functions in endoplasmic reticulum associated degradation (ERAD). Has ATPase activity. Belongs to the heat shock protein 90 family. Note: This description may include information from UniProtKB.
Protein type: Apoptosis; Heat shock protein; Secreted; Secreted, signal peptide
Chromosomal Location of Human Ortholog: 10 C1|10 43.05 cM
Cellular Component:  cytosol; endoplasmic reticulum; endoplasmic reticulum chaperone complex; endoplasmic reticulum lumen; endoplasmic reticulum membrane; midbody; perinuclear region of cytoplasm; plasma membrane; protein-containing complex; smooth endoplasmic reticulum
Molecular Function:  ATP binding; low-density lipoprotein particle receptor binding; nucleotide binding; protein binding; protein phosphatase binding; RNA binding; unfolded protein binding
Biological Process:  actin rod assembly; cellular response to ATP; negative regulation of apoptotic process; protein folding; regulation of phosphoprotein phosphatase activity; response to hypoxia; retrograde protein transport, ER to cytosol; ubiquitin-dependent ERAD pathway
Reference #:  P08113 (UniProtKB)
Alt. Names/Synonyms: 94 kDa glucose-regulated protein; Endoplasmic reticulum resident protein 99; Endoplasmin; ENPL; ERp99; gp96; GRP-94; Grp94; Heat shock protein 90 kDa beta member 1; heat shock protein 90, beta (Grp94), member 1; heat shock protein 90kDa beta (Grp94), member 1; Hsp90b1; OTTMUSP00000022393; Polymorphic tumor rejection antigen 1; TA-3; Targ2; Tra-1; Tra1; transforming growth factor alpha regulated gene 2; tumor rejection antigen (gp96) 1; Tumor rejection antigen gp96
Gene Symbols: Hsp90b1
Molecular weight: 92,476 Da
Basal Isoelectric point: 4.74  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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GRP94

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene