GRP94 Molecular chaperone that functions in the processing and transport of secreted proteins. When associated with CNPY3, required for proper folding of Toll-like receptors. Functions in endoplasmic reticulum associated degradation (ERAD). Has ATPase activity. Belongs to the heat shock protein 90 family. Note: This description may include information from UniProtKB.
Protein type: Apoptosis; Heat shock protein; Secreted; Secreted, signal peptide
Chromosomal Location of human Ortholog: 12q23.3
Cellular Component:  cytosol; endocytic vesicle lumen; endoplasmic reticulum; endoplasmic reticulum chaperone complex; endoplasmic reticulum lumen; endoplasmic reticulum membrane; extracellular region; melanosome; midbody; perinuclear region of cytoplasm; plasma membrane; protein-containing complex
Molecular Function:  ATP binding; calcium ion binding; low-density lipoprotein particle receptor binding; protein binding; protein phosphatase binding; RNA binding
Biological Process:  actin rod assembly; ATF6-mediated unfolded protein response; cellular protein metabolic process; cellular response to ATP; cytokine-mediated signaling pathway; negative regulation of apoptotic process; post-translational protein modification; protein folding in endoplasmic reticulum; protein transport; receptor-mediated endocytosis; regulation of phosphoprotein phosphatase activity; response to endoplasmic reticulum stress; response to hypoxia; retrograde protein transport, ER to cytosol; sequestering of calcium ion; toll-like receptor signaling pathway; ubiquitin-dependent ERAD pathway
Reference #:  P14625 (UniProtKB)
Alt. Names/Synonyms: 94 kDa glucose-regulated protein; ECGP; Endoplasmin; endothelial cell (HBMEC) glycoprotein; ENPL; epididymis luminal protein 35; epididymis secretory sperm binding protein Li 125m; glucose regulated protein, 94 kDa; GP96; gp96 homolog; GRP-94; GRP94; heat shock protein 90 beta family member 1; Heat shock protein 90 kDa beta member 1; heat shock protein 90kDa beta (Grp94), member 1; heat shock protein 90kDa beta family member 1; HEL-S-125m; HEL35; HSP90B1; stress-inducible tumor rejection antigen gp96; TRA1; tumor rejection antigen (gp96) 1; Tumor rejection antigen 1; Tumor rejection antigen-1 (gp96)
Gene Symbols: HSP90B1
Molecular weight: 92,469 Da
Basal Isoelectric point: 4.76  Predict pI for various phosphorylation states
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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GRP94

Protein Structure Not Found.


Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  CCLE  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene