GNMT Catalyzes the methylation of glycine by using S-adenosylmethionine (AdoMet) to form N-methylglycine (sarcosine) with the concomitant production of S-adenosylhomocysteine (AdoHcy). Possible crucial role in the regulation of tissue concentration of AdoMet and of metabolism of methionine. Belongs to the class I-like SAM-binding methyltransferase superfamily. Glycine N-methyltransferase family. Abundant in liver. Note: This description may include information from UniProtKB.
Protein type: Amino Acid Metabolism - glycine, serine and threonine; EC 2.1.1.20; Methyltransferase
Chromosomal Location of Human Ortholog: 17 22.9 cM|17 C
Cellular Component:  cytoplasm; cytosol
Molecular Function:  folic acid binding; glycine binding; glycine N-methyltransferase activity; identical protein binding; methyltransferase activity; S-adenosyl-L-methionine binding; transferase activity
Biological Process:  glycogen metabolic process; methionine metabolic process; methylation; one-carbon metabolic process; protein homotetramerization; regulation of gluconeogenesis; S-adenosylhomocysteine metabolic process; S-adenosylmethionine metabolic process; sarcosine metabolic process
Reference #:  Q9QXF8 (UniProtKB)
Alt. Names/Synonyms: glycine N methyl transferase; Glycine N-methyltransferase; Gnmt
Gene Symbols: Gnmt
Molecular weight: 32,675 Da
Basal Isoelectric point: 7.09  Predict pI for various phosphorylation states
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GNMT

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  BioGPS  |  Pfam  |  RCSB PDB  |  ENZYME  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene