Exportin-7
Mediates the nuclear export of proteins (cargos) with broad substrate specificity. In the nucleus binds cooperatively to its cargo and to the GTPase Ran in its active GTP-bound form. Docking of this trimeric complex to the nuclear pore complex (NPC) is mediated through binding to nucleoporins. Upon transit of a nuclear export complex into the cytoplasm, disassembling of the complex and hydrolysis of Ran-GTP to Ran-GDP (induced by RANBP1 and RANGAP1, respectively) cause release of the cargo from the export receptor. XPO7 then return to the nuclear compartment and mediate another round of transport. The directionality of nuclear export is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. Belongs to the exportin family. Strong expression in testis, thyroid and bone marrow, low expression in lung, liver and small intestine, no expression in thymus, and remaining tissues studied have moderate expression. Expressed in red blood cells; overexpressed in red blood cells (cytoplasm) of patients with hereditary non-spherocytic hemolytic anemia of unknown etiology. Note: This description may include information from UniProtKB.
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Protein type: Karyopherin; Nuclear export; Nuclear import |
Chromosomal Location of human Ortholog: 8p21.3 |
Cellular Component:
cytoplasm; nuclear pore; nucleus
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Molecular Function:
nuclear export signal receptor activity; protein binding; small GTPase binding
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Biological Process:
protein export from nucleus
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Reference #:
Q9UIA9
(UniProtKB)
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Alt. Names/Synonyms: Exp7; exportin 7; Exportin-7; KIAA0745; RAN binding protein 16; Ran-binding protein 16; RANBP16; XPO7
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Gene Symbols: XPO7
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Molecular weight:
123,907 Da
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Basal Isoelectric point:
5.91
Predict pI for various phosphorylation states
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