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DYRK1B
Dual-specificity kinase which possesses both serine/threonine and tyrosine kinase activities. Enhances the transcriptional activity of TCF1/HNF1A and FOXO1. Inhibits epithelial cell migration. Mediates colon carcinoma cell survival in mitogen-poor environments. Inhibits the SHH and WNT1 pathways, thereby enhancing adipogenesis. In addition, promotes expression of the gluconeogenic enzyme glucose-6-phosphatase (G6PC). Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MNB/DYRK subfamily. Highest expression in skeletal muscle, testis, heart and brain with little expression in colon or lung. Expressed in a variety of tumor cell lines. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: CMGC group; DYRK family; Dyrk1 subfamily; EC 2.7.12.1; Kinase, protein; Protein kinase, CMGC; Protein kinase, dual-specificity (non-receptor) |
| Chromosomal Location of human Ortholog: 19q13.2 |
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Cellular Component:
nucleus
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Molecular Function:
ATP binding; protein binding; protein kinase activity; protein serine/threonine kinase activity; protein serine/threonine/tyrosine kinase activity; protein tyrosine kinase activity; transcription coactivator activity
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Biological Process:
adipose tissue development; myoblast fusion; peptidyl-tyrosine phosphorylation; positive regulation of transcription, DNA-templated; protein phosphorylation
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Disease: Abdominal Obesity-metabolic Syndrome 3
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Reference #:
Q9Y463
(UniProtKB)
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Alt. Names/Synonyms: AOMS3; dual specificity tyrosine phosphorylation regulated kinase 1B; dual specificity tyrosine-(Y)-phosphorylation regulated kinase 1B; Dual specificity tyrosine-phosphorylation-regulated kinase 1B; dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1B; DYR1B; DYRK1B; Minibrain-related kinase; MIRK; Mirk protein kinase
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Gene Symbols: DYRK1B
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Molecular weight:
69,198 Da
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Basal Isoelectric point:
9.25
Predict pI for various phosphorylation states
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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