EPB41L1 May function to confer stability and plasticity to neuronal membrane via multiple interactions, including the spectrin-actin-based cytoskeleton, integral membrane channels and membrane-associated guanylate kinases. Highest expression in brain, lower in heart, kidney, pancreas, placenta, lung and skeletal muscle. 4 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Adaptor/scaffold
Chromosomal Location of Human Ortholog: 20q11.23
Cellular Component:  cytoskeleton; cytosol; plasma membrane
Molecular Function:  actin binding; protein binding; structural molecule activity
Biological Process:  cortical actin cytoskeleton organization
Disease: Mental Retardation, Autosomal Dominant 11
Reference #:  Q9H4G0 (UniProtKB)
Alt. Names/Synonyms: 4.1N; Band 4.1-like protein 1; DKFZp686H17242; E41L1; EPB41L1; erythrocyte membrane protein band 4.1-like 1; KIAA0338; MGC11072; neuron-type nonerythroid protein 4.1; Neuronal protein 4.1
Gene Symbols: EPB41L1
Molecular weight: 98,503 Da
Basal Isoelectric point: 5.43  Predict pI for various phosphorylation states
Select Structure to View Below

EPB41L1

Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein