ELMO1 Involved in cytoskeletal rearrangements required for phagocytosis of apoptotic cells and cell motility. Acts in association with DOCK1 and CRK. Was initially proposed to be required in complex with DOCK1 to activate Rac Rho small GTPases. May enhance the guanine nucleotide exchange factor (GEF) activity of DOCK1. Widely expressed, with a higher expression in the spleen and placenta. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Cytoskeletal; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 13|13 A2
Cellular Component:  cytoplasm; guanyl-nucleotide exchange factor complex; membrane; plasma membrane
Molecular Function:  protein binding; SH3 domain binding
Biological Process:  actin cytoskeleton organization; actin filament-based process; apoptotic process; cell migration; cell motility; phagocytosis; phagocytosis, engulfment; Rac protein signal transduction
Reference #:  Q8BPU7 (UniProtKB)
Alt. Names/Synonyms: 6330578D22Rik; AI173001; C230095H21Rik; CED-12; CED-12 homolog; Elmo1; engulfment and cell motility 1, ced-12 homolog (C. elegans); Engulfment and cell motility protein 1; KIAA0281; mKIAA0281; Protein ced-12 homolog
Gene Symbols: Elmo1
Molecular weight: 83,936 Da
Basal Isoelectric point: 5.89  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene