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ELMO1
Involved in cytoskeletal rearrangements required for phagocytosis of apoptotic cells and cell motility. Acts in association with DOCK1 and CRK. Was initially proposed to be required in complex with DOCK1 to activate Rac Rho small GTPases. May enhance the guanine nucleotide exchange factor (GEF) activity of DOCK1. Widely expressed, with a higher expression in the spleen and placenta. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: Cytoskeletal; Motility/polarity/chemotaxis |
| Chromosomal Location of Human Ortholog: 7p14.2-p14.1 |
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Cellular Component:
cytoplasm; cytosol; guanyl-nucleotide exchange factor complex; plasma membrane
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Molecular Function:
protein binding; SH3 domain binding
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Biological Process:
actin cytoskeleton organization; apoptotic process; cell migration; cell motility; Fc-gamma receptor signaling pathway involved in phagocytosis; phagocytosis, engulfment; Rac protein signal transduction; regulation of defense response to virus by virus; vascular endothelial growth factor receptor signaling pathway
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Reference #:
Q92556
(UniProtKB)
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Alt. Names/Synonyms: CED-12; ced-12 homolog 1; CED12; ELMO-1; ELMO1; engulfment and cell motility 1; Engulfment and cell motility protein 1; KIAA0281; MGC126406; Protein ced-12 homolog
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Gene Symbols: ELMO1
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Molecular weight:
83,829 Da
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Basal Isoelectric point:
5.89
Predict pI for various phosphorylation states
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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