ELMO1 Involved in cytoskeletal rearrangements required for phagocytosis of apoptotic cells and cell motility. Acts in association with DOCK1 and CRK. Was initially proposed to be required in complex with DOCK1 to activate Rac Rho small GTPases. May enhance the guanine nucleotide exchange factor (GEF) activity of DOCK1. Widely expressed, with a higher expression in the spleen and placenta. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Cytoskeletal; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 7p14.2-p14.1
Cellular Component:  cytoplasm; cytosol; guanyl-nucleotide exchange factor complex; plasma membrane
Molecular Function:  protein binding; SH3 domain binding
Biological Process:  actin cytoskeleton organization; apoptotic process; cell migration; cell motility; Fc-gamma receptor signaling pathway involved in phagocytosis; phagocytosis, engulfment; Rac protein signal transduction; regulation of defense response to virus by virus; vascular endothelial growth factor receptor signaling pathway
Reference #:  Q92556 (UniProtKB)
Alt. Names/Synonyms: CED-12; ced-12 homolog 1; CED12; ELMO-1; ELMO1; engulfment and cell motility 1; Engulfment and cell motility protein 1; KIAA0281; MGC126406; Protein ced-12 homolog
Gene Symbols: ELMO1
Molecular weight: 83,829 Da
Basal Isoelectric point: 5.89  Predict pI for various phosphorylation states
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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ELMO1

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  InnateDB  |  Ensembl Protein