DOT1L Histone methyltransferase. Methylates 'Lys-79' of histone H3. Nucleosomes are preferred as substrate compared to free histones. Binds to DNA. Belongs to the class I-like SAM-binding methyltransferase superfamily. DOT1 family. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Amino Acid Metabolism - lysine degradation; EC; Methyltransferase; Methyltransferase, protein lysine
Chromosomal Location of human Ortholog: 19p13.3
Cellular Component:  cytoplasm; intracellular membrane-bounded organelle; nucleoplasm; nucleus; protein-containing complex
Molecular Function:  DNA binding; histone H3K79 methyltransferase activity; histone H3K79 trimethyltransferase activity; histone methyltransferase activity; nucleic acid binding; protein binding
Biological Process:  DNA damage checkpoint signaling; DNA repair; gene expression; heterochromatin formation; histone H3-K79 methylation; positive regulation of cell population proliferation; positive regulation of transcription by RNA polymerase II; regulation of receptor signaling pathway via JAK-STAT; regulation of transcription regulatory region DNA binding; telomere organization
Reference #:  Q8TEK3 (UniProtKB)
Alt. Names/Synonyms: DKFZp586P1823; DOT1; DOT1 like histone H3K79 methyltransferase; DOT1 like histone lysine methyltransferase; DOT1-like histone methyltransferase; DOT1-like protein; DOT1-like, histone H3 methyltransferase; DOT1-like, histone H3 methyltransferase (S. cerevisiae); DOT1L; H3-K79-HMTase; Histone H3-K79 methyltransferase; histone methyltransferase DOT1L; Histone-lysine N-methyltransferase, H3 lysine-79 specific; KIAA1814; KMT4; Lysine N-methyltransferase 4
Gene Symbols: DOT1L
Molecular weight: 164,856 Da
Basal Isoelectric point: 9.26  Predict pI for various phosphorylation states
CST Pathways:  Histone Methylation
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  ENZYME  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  InnateDB  |  Ensembl Protein