DERL2 Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal glycoproteins, but not that of misfolded nonglycoproteins. May act by forming a channel that allows the retrotranslocation of misfolded glycoproteins into the cytosol where they are ubiquitinated and degraded by the proteasome. May mediate the interaction between VCP and misfolded glycoproteins. May also be involved in endoplasmic reticulum stress-induced pre-emptive quality control, a mechanism that selectively attenuates the translocation of newly synthesized proteins into the endoplasmic reticulum and reroutes them to the cytosol for proteasomal degradation. (Microbial infection) In contrast to DERL1, it is not involved in the degradation of MHC class I heavy chains following infection by cytomegaloviruses. Belongs to the derlin family. Ubiquitous. Overexpressed in various hepatocarcinomas. Note: This description may include information from UniProtKB.
Protein type: Endoplasmic reticulum; Membrane protein, integral; Membrane protein, multi-pass
Chromosomal Location of Human Ortholog: 17p13.2
Cellular Component:  early endosome; endoplasmic reticulum; endoplasmic reticulum membrane; endoplasmic reticulum quality control compartment; integral component of endoplasmic reticulum membrane; late endosome
Molecular Function:  protein binding
Biological Process:  endoplasmic reticulum mannose trimming; endoplasmic reticulum unfolded protein response; negative regulation of retrograde protein transport, ER to cytosol; positive regulation of cell growth; positive regulation of cell proliferation; retrograde protein transport, ER to cytosol; suckling behavior; ubiquitin-dependent ERAD pathway
Reference #:  Q9GZP9 (UniProtKB)
Alt. Names/Synonyms: carcinoma related; CGI-101; Degradation in endoplasmic reticulum protein 2; Der1-like domain family, member 2; Der1-like protein 2; DER2; DERL2; Derlin-2; DERtrin-2; F-LAN-1; F-LANa; FLANA
Gene Symbols: DERL2
Molecular weight: 27,567 Da
Basal Isoelectric point: 6.73  Predict pI for various phosphorylation states
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  InnateDB