CIRBP Cold-inducible mRNA binding protein that plays a protective role in the genotoxic stress response by stabilizing transcripts of genes involved in cell survival. Acts as a translational activator. Seems to play an essential role in cold-induced suppression of cell proliferation. Binds specifically to the 3'-untranslated regions (3'-UTRs) of stress-responsive transcripts RPA2 and TXN. Acts as a translational repressor. Promotes assembly of stress granules (SGs), when overexpressed. Ubiquitous. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: RNA-binding; Spliceosome; Translation
Chromosomal Location of Human Ortholog: 19p13.3
Cellular Component:  cytoplasm; cytoplasmic stress granule; nucleolus; nucleoplasm; nucleus
Molecular Function:  mRNA 3'-UTR binding; protein binding; small ribosomal subunit rRNA binding; translation repressor activity
Biological Process:  mRNA stabilization; negative regulation of translation; positive regulation of translation; response to UV; stress granule assembly
Reference #:  Q14011 (UniProtKB)
Alt. Names/Synonyms: A18 hnRNP; A18HNRNP; CIRBP; CIRP; cold inducible RNA binding protein; cold inducible RNA-binding protein; Cold-inducible RNA-binding protein; glycine-rich RNA binding protein; Glycine-rich RNA-binding protein CIRP
Gene Symbols: CIRBP
Molecular weight: 18,648 Da
Basal Isoelectric point: 9.51  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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CIRBP

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  InnateDB