CIRBP
Cold-inducible mRNA binding protein that plays a protective role in the genotoxic stress response by stabilizing transcripts of genes involved in cell survival. Acts as a translational activator. Seems to play an essential role in cold-induced suppression of cell proliferation. Binds specifically to the 3'-untranslated regions (3'-UTRs) of stress-responsive transcripts RPA2 and TXN. Acts as a translational repressor. Promotes assembly of stress granules (SGs), when overexpressed. Ubiquitous. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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Protein type: RNA-binding; Spliceosome; Translation |
Chromosomal Location of human Ortholog: 19p13.3 |
Cellular Component:
cytoplasm; cytoplasmic stress granule; nucleoplasm; nucleus; spliceosomal complex
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Molecular Function:
mRNA 3'-UTR binding; protein binding; RNA binding; small ribosomal subunit rRNA binding; translation repressor activity
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Biological Process:
mRNA stabilization; negative regulation of translation; positive regulation of mRNA splicing, via spliceosome; positive regulation of translation; response to cold; response to UV; stress granule assembly
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Reference #:
Q14011
(UniProtKB)
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Alt. Names/Synonyms: A18 hnRNP; A18HNRNP; CIRBP; CIRP; cold inducible RNA binding protein; cold inducible RNA-binding protein; Cold-inducible RNA-binding protein; glycine-rich RNA binding protein; Glycine-rich RNA-binding protein CIRP; testicular tissue protein Li 39
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Gene Symbols: CIRBP
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Molecular weight:
18,648 Da
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Basal Isoelectric point:
9.51
Predict pI for various phosphorylation states
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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