CHD-8 DNA helicase that acts as a chromatin remodeling factor and regulates transcription. Acts as a transcription repressor by remodeling chromatin structure and recruiting histone H1 to target genes. Suppresses p53/TP53-mediated apoptosis by recruiting histone H1 and preventing p53/TP53 transactivation activity. Acts as a negative regulator of Wnt signaling pathway by regulating beta-catenin (CTNNB1) activity. Negatively regulates CTNNB1-targeted gene expression by being recruited specifically to the promoter regions of several CTNNB1 responsive genes. Involved in both enhancer blocking and epigenetic remodeling at chromatin boundary via its interaction with CTCF. Acts as a suppressor of STAT3 activity by suppressing the LIF-induced STAT3 transcriptional activity. Also acts as a transcription activator via its interaction with ZNF143 by participating in efficient U6 RNA polymerase III transcription. Belongs to the SNF2/RAD54 helicase family. CHD8 subfamily. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: EC; Helicase; Transcription factor
Chromosomal Location of human Ortholog: 14q11.2
Cellular Component:  MLL1 complex; nucleoplasm; nucleus; protein-containing complex
Molecular Function:  armadillo repeat domain binding; ATP binding; beta-catenin binding; chromatin binding; DNA binding; DNA helicase activity; DNA-dependent ATPase activity; histone binding; methylated histone binding; p53 binding; protein binding
Biological Process:  ATP-dependent chromatin remodeling; brain development; digestive tract development; DNA duplex unwinding; in utero embryonic development; negative regulation of canonical Wnt signaling pathway; negative regulation of fibroblast apoptotic process; negative regulation of transcription by RNA polymerase II; negative regulation of transcription, DNA-templated; positive regulation of transcription by RNA polymerase II; positive regulation of transcription by RNA polymerase III; positive regulation of transcription, DNA-templated; prepulse inhibition; social behavior; Wnt signaling pathway
Disease: Autism, Susceptibility To, 18
Reference #:  Q9HCK8 (UniProtKB)
Alt. Names/Synonyms: ATP-dependent helicase CHD8; AUTS18; axis duplication inhibitor; beta-catenin binding protein-like; CHD-8; CHD8; chromodomain helicase DNA binding protein 8; Chromodomain-helicase-DNA-binding protein 8; DKFZp686N17164; duplin; Helicase with SNF2 domain 1; HELSNF1; KIAA1564
Gene Symbols: CHD8
Molecular weight: 290,519 Da
Basal Isoelectric point: 6.04  Predict pI for various phosphorylation states
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  CCLE  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  ENZYME  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  InnateDB