Calreticulin Calcium-binding chaperone that promotes folding, oligomeric assembly and quality control in the endoplasmic reticulum (ER) via the calreticulin/calnexin cycle. This lectin interacts transiently with almost all of the monoglucosylated glycoproteins that are synthesized in the ER. Interacts with the DNA-binding domain of NR3C1 and mediates its nuclear export. Involved in maternal gene expression regulation. May participate in oocyte maturation via the regulation of calcium homeostasis. Belongs to the calreticulin family. Note: This description may include information from UniProtKB.
Protein type: Calcium-binding; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Secreted; Secreted, signal peptide
Chromosomal Location of Human Ortholog: 8 C2|8 41.21 cM
Cellular Component:  acrosomal vesicle; cell surface; collagen-containing extracellular matrix; cytoplasm; cytosol; endoplasmic reticulum; endoplasmic reticulum lumen; endoplasmic reticulum quality control compartment; external side of plasma membrane; extracellular space; Golgi apparatus; intracellular membrane-bounded organelle; membrane; MHC class I peptide loading complex; nuclear envelope; nucleus; perinuclear region of cytoplasm; polysome; protein-containing complex; sarcoplasmic reticulum; smooth endoplasmic reticulum
Molecular Function:  androgen receptor binding; calcium ion binding; carbohydrate binding; hormone binding; integrin binding; iron ion binding; metal ion binding; mRNA binding; peptide binding; protein binding; ubiquitin protein ligase binding; unfolded protein binding
Biological Process:  cellular senescence; cortical actin cytoskeleton organization; negative regulation of cell cycle arrest; negative regulation of intracellular steroid hormone receptor signaling pathway; negative regulation of neuron differentiation; negative regulation of retinoic acid receptor signaling pathway; negative regulation of transcription by RNA polymerase II; negative regulation of transcription, DNA-templated; negative regulation of translation; negative regulation of trophoblast cell migration; peptide antigen assembly with MHC class I protein complex; positive regulation of cell cycle; positive regulation of cell proliferation; positive regulation of dendritic cell chemotaxis; positive regulation of endothelial cell migration; positive regulation of gene expression; positive regulation of NIK/NF-kappaB signaling; positive regulation of phagocytosis; positive regulation of substrate adhesion-dependent cell spreading; protein export from nucleus; protein folding; protein localization to nucleus; protein stabilization; regulation of meiotic nuclear division
Reference #:  P14211 (UniProtKB)
Alt. Names/Synonyms: Calr; Calregulin; Calreticulin; CRP55; CRT; Endoplasmic reticulum resident protein 60; ERp60; HACBP; OTTMUSP00000025211
Gene Symbols: Calr
Molecular weight: 47,995 Da
Basal Isoelectric point: 4.33  Predict pI for various phosphorylation states
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene  |  NURSA