Calreticulin Calcium-binding chaperone that promotes folding, oligomeric assembly and quality control in the endoplasmic reticulum (ER) via the calreticulin/calnexin cycle. This lectin interacts transiently with almost all of the monoglucosylated glycoproteins that are synthesized in the ER. Interacts with the DNA-binding domain of NR3C1 and mediates its nuclear export. Involved in maternal gene expression regulation. May participate in oocyte maturation via the regulation of calcium homeostasis. Belongs to the calreticulin family. Note: This description may include information from UniProtKB.
Protein type: Calcium-binding; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Secreted; Secreted, signal peptide
Chromosomal Location of Human Ortholog: 19p13.13
Cellular Component:  acrosomal vesicle; cell surface; collagen-containing extracellular matrix; cytoplasm; cytosol; endocytic vesicle lumen; endoplasmic reticulum; endoplasmic reticulum lumen; endoplasmic reticulum quality control compartment; endoplasmic reticulum-Golgi intermediate compartment membrane; external side of plasma membrane; extracellular region; extracellular space; Golgi apparatus; integral component of lumenal side of endoplasmic reticulum membrane; membrane; MHC class I peptide loading complex; nuclear envelope; nucleus; perinuclear region of cytoplasm; phagocytic vesicle membrane; polysome; sarcoplasmic reticulum lumen; smooth endoplasmic reticulum
Molecular Function:  androgen receptor binding; calcium ion binding; carbohydrate binding; chaperone binding; complement component C1q binding; DNA binding; hormone binding; integrin binding; iron ion binding; mRNA binding; peptide binding; protein binding; protein binding involved in protein folding; ubiquitin protein ligase binding; unfolded protein binding; zinc ion binding
Biological Process:  antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent; antigen processing and presentation of peptide antigen via MHC class I; ATF6-mediated unfolded protein response; cardiac muscle cell differentiation; cellular calcium ion homeostasis; cellular response to lithium ion; cellular senescence; cortical actin cytoskeleton organization; glucocorticoid receptor signaling pathway; negative regulation of cell cycle arrest; negative regulation of intracellular steroid hormone receptor signaling pathway; negative regulation of neuron differentiation; negative regulation of retinoic acid receptor signaling pathway; negative regulation of transcription by RNA polymerase II; negative regulation of transcription, DNA-templated; negative regulation of translation; negative regulation of trophoblast cell migration; peptide antigen assembly with MHC class I protein complex; positive regulation of cell cycle; positive regulation of cell proliferation; positive regulation of dendritic cell chemotaxis; positive regulation of endothelial cell migration; positive regulation of gene expression; positive regulation of NIK/NF-kappaB signaling; positive regulation of phagocytosis; positive regulation of substrate adhesion-dependent cell spreading; protein export from nucleus; protein folding; protein folding in endoplasmic reticulum; protein localization to nucleus; protein maturation by protein folding; protein stabilization; receptor-mediated endocytosis; regulation of apoptotic process; regulation of meiotic nuclear division; regulation of transcription, DNA-templated; response to drug; response to estradiol; response to testosterone; sequestering of calcium ion; spermatogenesis; vesicle fusion with endoplasmic reticulum-Golgi intermediate compartment (ERGIC) membrane
Disease: Myelofibrosis; Thrombocythemia 1
Reference #:  P27797 (UniProtKB)
Alt. Names/Synonyms: autoantigen Ro; CALR; Calregulin; Calreticulin; calreticulin); cC1qR; CRP55; CRT; CRTC; Endoplasmic reticulum resident protein 60; epididymis secretory sperm binding protein Li 99n; ERp60; FLJ26680; grp60; HACBP; HEL-S-99n; RO; Sicca syndrome antigen A (autoantigen Ro; SSA
Gene Symbols: CALR
Molecular weight: 48,142 Da
Basal Isoelectric point: 4.29  Predict pI for various phosphorylation states
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  NURSA