BHMT Involved in the regulation of homocysteine metabolism. Converts betaine and homocysteine to dimethylglycine and methionine, respectively. This reaction is also required for the irreversible oxidation of choline. Found exclusively in liver and kidney. Note: This description may include information from UniProtKB.
Protein type: Amino Acid Metabolism - cysteine and methionine; Amino Acid Metabolism - glycine, serine and threonine; EC; Methyltransferase
Chromosomal Location of human Ortholog: 5q14.1
Cellular Component:  cytosol; extracellular exosome; nucleus
Molecular Function:  betaine-homocysteine S-methyltransferase activity; zinc ion binding
Biological Process:  'de novo' L-methionine biosynthetic process; amino-acid betaine catabolic process; amino-acid betaine metabolic process; L-methionine salvage; methionine biosynthetic process; protein methylation; regulation of homocysteine metabolic process; S-adenosylmethionine metabolic process
Reference #:  Q93088 (UniProtKB)
Alt. Names/Synonyms: betaine homocysteine methyltransferase; betaine--homocysteine S-methyltransferase; Betaine--homocysteine S-methyltransferase 1; betaine-homocysteine methyltransferase; BHMT; BHMT1; epididymis secretory sperm binding protein Li 61p; HEL-S-61p
Gene Symbols: BHMT
Molecular weight: 44,998 Da
Basal Isoelectric point: 6.58  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  ENZYME  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene