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BHMT
Involved in the regulation of homocysteine metabolism. Converts betaine and homocysteine to dimethylglycine and methionine, respectively. This reaction is also required for the irreversible oxidation of choline. Found exclusively in liver and kidney. Note: This description may include information from UniProtKB.
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| Protein type: Amino Acid Metabolism - cysteine and methionine; Amino Acid Metabolism - glycine, serine and threonine; EC 2.1.1.5; Methyltransferase |
| Chromosomal Location of human Ortholog: 5q14.1 |
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Cellular Component:
cytosol; extracellular exosome; nucleus
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Molecular Function:
betaine-homocysteine S-methyltransferase activity; zinc ion binding
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Biological Process:
'de novo' L-methionine biosynthetic process; amino-acid betaine catabolic process; amino-acid betaine metabolic process; L-methionine salvage; methionine biosynthetic process; protein methylation; regulation of homocysteine metabolic process; S-adenosylmethionine metabolic process
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Reference #:
Q93088
(UniProtKB)
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Alt. Names/Synonyms: betaine homocysteine methyltransferase; betaine--homocysteine S-methyltransferase; Betaine--homocysteine S-methyltransferase 1; betaine-homocysteine methyltransferase; BHMT; BHMT1; epididymis secretory sperm binding protein Li 61p; HEL-S-61p
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Gene Symbols: BHMT
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Molecular weight:
44,998 Da
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Basal Isoelectric point:
6.58
Predict pI for various phosphorylation states
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