AUP1
May play a role in the translocation of terminally misfolded proteins from the endoplasmic reticulum lumen to the cytoplasm and their degradation by the proteasome. Belongs to the AUP1 family. Detected in blood platelets and leukocytes (at protein level). Ubiquitous. Highly expressed in placenta, liver, kidney, skeletal muscle, heart and brain. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
|
Protein type: Endoplasmic reticulum; Membrane protein, integral; Transferase |
Chromosomal Location of human Ortholog: 2p13.1 |
Cellular Component:
autophagosome; cytoplasmic vesicle; endoplasmic reticulum; endoplasmic reticulum membrane; lipid droplet; membrane
|
Molecular Function:
protein binding; ubiquitin binding; ubiquitin conjugating enzyme binding; ubiquitin protein ligase binding
|
Biological Process:
ER-associated misfolded protein catabolic process; lipid droplet formation; lipid droplet organization; lipophagy; protein localization to lipid droplet; response to virus; retrograde protein transport, ER to cytosol; ubiquitin-dependent ERAD pathway
|
Reference #:
Q9Y679
(UniProtKB)
|
Alt. Names/Synonyms: Ancient ubiquitous protein 1; AUP1; AUP1 lipid droplet regulating VLDL assembly factor; Lipid droplet-regulating VLDL assembly factor AUP1
|
Gene Symbols: AUP1
|
Molecular weight:
45,787 Da
|
Basal Isoelectric point:
8.96
Predict pI for various phosphorylation states
|
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
|