AUP1 May play a role in the translocation of terminally misfolded proteins from the endoplasmic reticulum lumen to the cytoplasm and their degradation by the proteasome. Belongs to the AUP1 family. Detected in blood platelets and leukocytes (at protein level). Ubiquitous. Highly expressed in placenta, liver, kidney, skeletal muscle, heart and brain. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Endoplasmic reticulum; Membrane protein, integral; Transferase
Chromosomal Location of human Ortholog: 2p13.1
Cellular Component:  autophagosome; cytoplasmic vesicle; endoplasmic reticulum; endoplasmic reticulum membrane; Hrd1p ubiquitin ligase ERAD-L complex; lipid droplet; membrane
Molecular Function:  protein binding; ubiquitin binding; ubiquitin conjugating enzyme binding; ubiquitin protein ligase binding; ubiquitin-protein transferase activator activity
Biological Process:  ER-associated misfolded protein catabolic process; lipid droplet formation; lipid droplet organization; lipophagy; protein localization to lipid droplet; regulation of catalytic activity; response to virus; retrograde protein transport, ER to cytosol; ubiquitin-dependent ERAD pathway
Reference #:  Q9Y679 (UniProtKB)
Alt. Names/Synonyms: Ancient ubiquitous protein 1; AUP1; AUP1 lipid droplet regulating VLDL assembly factor
Gene Symbols: AUP1
Molecular weight: 45,787 Da
Basal Isoelectric point: 8.96  Predict pI for various phosphorylation states
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene