ARF4 GTP-binding protein that functions as an allosteric activator of the cholera toxin catalytic subunit, an ADP-ribosyltransferase. Involved in protein trafficking; may modulate vesicle budding and uncoating within the Golgi apparatus. Belongs to the small GTPase superfamily. Arf family. Note: This description may include information from UniProtKB.
Protein type: G protein; G protein, monomeric; G protein, monomeric, ARF; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 14 A3|14 16.09 cM
Cellular Component:  cytoplasm; cytosol; dendritic spine; glutamatergic synapse; Golgi apparatus; membrane; plasma membrane; ruffle membrane
Molecular Function:  epidermal growth factor receptor binding; GTP binding; nucleotide binding; protein binding
Biological Process:  activation of phospholipase D activity; apical protein localization; cell migration; dendritic spine development; epidermal growth factor receptor signaling pathway; establishment or maintenance of epithelial cell apical/basal polarity; Golgi to plasma membrane transport; intracellular protein transport; learning; negative regulation of apoptotic process; positive regulation of transcription by RNA polymerase II; protein ADP-ribosylation; protein localization to cilium; protein transport; regulation of postsynapse organization; regulation of reactive oxygen species metabolic process; regulation of synapse organization; retrograde vesicle-mediated transport, Golgi to ER; vesicle-mediated transport
Reference #:  P61750 (UniProtKB)
Alt. Names/Synonyms: AA407803; ADP-ribosylation factor 4; Arf4
Gene Symbols: Arf4
Molecular weight: 20,397 Da
Basal Isoelectric point: 6.59  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  STRING  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene