ARF4 GTP-binding protein that functions as an allosteric activator of the cholera toxin catalytic subunit, an ADP-ribosyltransferase. Involved in protein trafficking; may modulate vesicle budding and uncoating within the Golgi apparatus. Belongs to the small GTPase superfamily. Arf family. Note: This description may include information from UniProtKB.
Protein type: G protein; G protein, monomeric; G protein, monomeric, ARF; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 3p14.3
Cellular Component:  cytosol; dendritic spine; glutamatergic synapse; ruffle membrane
Molecular Function:  ARF guanyl-nucleotide exchange factor activity; epidermal growth factor receptor binding; GTP binding; GTPase activity; protein binding
Biological Process:  activation of phospholipase D activity; apical protein localization; brain development; cell migration; dendritic spine development; epidermal growth factor receptor signaling pathway; ER to Golgi vesicle-mediated transport; establishment or maintenance of epithelial cell apical/basal polarity; learning; negative regulation of apoptotic process; positive regulation of transcription by RNA polymerase II; protein ADP-ribosylation; protein localization to cilium; regulation of postsynapse organization; regulation of reactive oxygen species metabolic process; response to axon injury; retrograde vesicle-mediated transport, Golgi to ER
Reference #:  P18085 (UniProtKB)
Alt. Names/Synonyms: ADP ribosylation factor 4; ADP-ribosylation factor 2; ADP-ribosylation factor 4; ARF2; ARF4
Gene Symbols: ARF4
Molecular weight: 20,511 Da
Basal Isoelectric point: 6.6  Predict pI for various phosphorylation states
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene