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ARF4
GTP-binding protein that functions as an allosteric activator of the cholera toxin catalytic subunit, an ADP-ribosyltransferase. Involved in protein trafficking; may modulate vesicle budding and uncoating within the Golgi apparatus. Belongs to the small GTPase superfamily. Arf family. Note: This description may include information from UniProtKB.
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| Protein type: G protein; G protein, monomeric; G protein, monomeric, ARF; Motility/polarity/chemotaxis |
| Chromosomal Location of human Ortholog: 3p14.3 |
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Cellular Component:
cytoplasm; cytosol; dendritic spine; glutamatergic synapse; Golgi apparatus; plasma membrane; ruffle membrane
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Molecular Function:
epidermal growth factor receptor binding; GTP binding; GTPase activity; guanyl-nucleotide exchange factor activity; NAD+-protein-arginine ADP-ribosyltransferase activity; protein binding
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Biological Process:
activation of phospholipase D activity; apical protein localization; cell migration; cilium assembly; dendritic spine development; endoplasmic reticulum to Golgi vesicle-mediated transport; establishment or maintenance of epithelial cell apical/basal polarity; intracellular protein transport; learning; negative regulation of apoptotic process; positive regulation of transcription by RNA polymerase II; protein localization to cilium; regulation of postsynapse organization; regulation of reactive oxygen species metabolic process; retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum; vesicle-mediated transport
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Reference #:
P18085
(UniProtKB)
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Alt. Names/Synonyms: ADP ribosylation factor 4; ADP-ribosylation factor 2; ADP-ribosylation factor 4; ARF2; ARF4
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Gene Symbols: ARF4
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Molecular weight:
20,511 Da
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Basal Isoelectric point:
6.6
Predict pI for various phosphorylation states
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