BAF53B Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner. Belongs to the neuron-specific chromatin remodeling complex (nBAF complex), as such plays a role in remodeling mononucleosomes in an ATP-dependent fashion, and is required for postmitotic neural development and dendritic outgrowth. During neural development a switch from a stem/progenitor to a postmitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to postmitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth. ACTL6B/BAF53B is not essential for assembly of the nBAF complex but is required for targeting the complex and CREST to the promoter of genes essential for dendritic growth. Belongs to the actin family. Note: This description may include information from UniProtKB.
Protein type: Cytoskeletal
Chromosomal Location of Human Ortholog: 5|5 G2
Cellular Component:  nBAF complex; NuA4 histone acetyltransferase complex; nucleolus; nucleus; SWI/SNF complex
Molecular Function:  chromatin binding; protein binding
Biological Process:  ATP-dependent chromatin remodeling; chromatin assembly or disassembly; chromatin organization; chromatin remodeling; histone H4 acetylation; nervous system development; regulation of transcription by RNA polymerase II
Reference #:  Q99MR0 (UniProtKB)
Alt. Names/Synonyms: 53 kDa BRG1-associated factor B; ACL6B; actin-like 6; actin-like 6B; Actin-like protein 6B; Actin-related protein Baf53b; Actl6; Actl6b; ArpN-alpha; ArpNa; BAF53B; BRG1-associated factor 53B; OTTMUSP00000024596
Gene Symbols: Actl6b
Molecular weight: 46,891 Da
Basal Isoelectric point: 5.48  Predict pI for various phosphorylation states
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BAF53B

Protein Structure Not Found.

Cross-references to other databases:  STRING  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene