Abi-2 Regulator of actin cytoskeleton dynamics underlying cell motility and adhesion. Functions as a component of the WAVE complex, which activates actin nucleating machinery Arp2/3 to drive lamellipodia formation. Acts as regulator and substrate of nonreceptor tyrosine kinases ABL1 and ABL2 involved in processes linked to cell growth and differentiation. Positively regulates ABL1-mediated phosphorylation of ENAH, which is required for proper polymerization of nucleated actin filaments at the leading edge. Contributes to the regulation of actin assembly at the tips of neuron projections. In particular, controls dendritic spine morphogenesis and may promote dendritic spine specification toward large mushroom-type spines known as repositories of memory in the brain. In hippocampal neurons, may mediate actin-dependent BDNF-NTRK2 early endocytic trafficking that triggers dendrite outgrowth. Participates in ocular lens morphogenesis, likely by regulating lamellipodia-driven adherens junction formation at the epithelial cell-secondary lens fiber interface. Also required for nascent adherens junction assembly in epithelial cells. Belongs to the ABI family. Widely expressed. Abundant in testes, ovary, thymus, and colon, with lower but detectable levels in prostate, peripheral blood leukocytes, and spleen. 4 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Adaptor/scaffold; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 2q33.2
Cellular Component:  adherens junction; cytoplasm; cytoskeleton; cytosol; dendritic spine; filopodium tip; lamellipodium; nucleus; SCAR complex
Molecular Function:  cytoskeletal adaptor activity; DNA binding; kinase binding; proline-rich region binding; protein binding; SH3 domain binding; ubiquitin protein ligase binding
Biological Process:  actin polymerization or depolymerization; cell migration; cytoskeleton organization; lens fiber cell morphogenesis; peptidyl-tyrosine phosphorylation; positive regulation of Arp2/3 complex-mediated actin nucleation; Rac protein signal transduction; regulation of dendritic spine morphogenesis; viral process
Reference #:  Q9NYB9 (UniProtKB)
Alt. Names/Synonyms: Abelson interactor 2; Abi-2; ABI2; ABI2B; abl binding protein 3; Abl interactor 2; Abl-binding protein 3; abl-interacting protein 1 (SH3-containing protein); abl-interactor 2; abl-interactor protein 2b; AblBP3; AIP-1; arg protein tyrosine kinase-binding protein; Arg-binding protein 1; ArgBP1; ARGBPIA; argBPIB; SSH3BP2
Gene Symbols: ABI2
Molecular weight: 55,663 Da
Basal Isoelectric point: 5.82  Predict pI for various phosphorylation states
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Protein Structure Not Found.

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