14-3-3 gamma
Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. Belongs to the 14-3-3 family. Highly expressed in brain, skeletal muscle, and heart. Note: This description may include information from UniProtKB.
|
Protein type: Adaptor/scaffold |
Chromosomal Location of mouse Ortholog: 5|5 G2 |
Cellular Component:
cytoplasm; cytosol; presynapse; synapse; vesicle
|
Molecular Function:
identical protein binding; insulin-like growth factor receptor binding; protein binding; protein domain specific binding; protein kinase C binding; receptor tyrosine kinase binding
|
Biological Process:
cellular response to insulin stimulus; protein targeting; regulation of neuron differentiation; regulation of synaptic plasticity; signal transduction
|
Reference #:
P61982
(UniProtKB)
|
Alt. Names/Synonyms: 14-3-3 gamma; 14-3-3 protein gamma; 14-3-3 protein gamma subtype; 14-3-3 protein gamma, N-terminally processed; 14-3-3gamma; 1433G; 3-monooxgenase/tryptophan 5-monooxgenase activation protein, gamma polypeptide; 3-monooxgenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide; 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide; D7Bwg1348e; OTTMUSP00000017492; tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide; Ywhag
|
Gene Symbols: Ywhag
|
Molecular weight:
28,303 Da
|
Basal Isoelectric point:
4.8
Predict pI for various phosphorylation states
|
CST Pathways:
Apoptosis Regulation
|
G2/M DNA Damage Checkpoint
|
Growth And Differentiation Control by MAPKs
|
Mitochondrial Control of Apoptosis
|
PI3K/Akt Signaling
|
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
|