14-3-3 gamma Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. Belongs to the 14-3-3 family. Highly expressed in brain, skeletal muscle, and heart. Note: This description may include information from UniProtKB.
Protein type: Adaptor/scaffold
Chromosomal Location of human Ortholog: 7q11.23
Cellular Component:  cytosol; mitochondrion; presynapse
Molecular Function:  identical protein binding; insulin-like growth factor receptor binding; protein binding; protein domain specific binding; protein kinase C binding; protein kinase C inhibitor activity; receptor tyrosine kinase binding
Biological Process:  cellular response to insulin stimulus; ciliary basal body-plasma membrane docking; G2/M transition of mitotic cell cycle; membrane organization; negative regulation of protein kinase activity; negative regulation of protein serine/threonine kinase activity; positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway; protein targeting; regulation of G2/M transition of mitotic cell cycle; regulation of neuron differentiation; regulation of signal transduction; regulation of synaptic plasticity
Disease: Epileptic Encephalopathy, Early Infantile, 56
Reference #:  P61981 (UniProtKB)
Alt. Names/Synonyms: 14-3-3 gamma; 14-3-3 protein gamma; 14-3-3 protein gamma, N-terminally processed; 14-3-3GAMMA; 1433G; EIEE56; KCIP-1; PPP1R170; Protein kinase C inhibitor protein 1; protein phosphatase 1, regulatory subunit 170; tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein gamma; tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide; YWHAG
Gene Symbols: YWHAG
Molecular weight: 28,303 Da
Basal Isoelectric point: 4.8  Predict pI for various phosphorylation states
CST Pathways:  Apoptosis Regulation  |  G2/M DNA Damage Checkpoint  |  Growth And Differentiation Control by MAPKs  |  Mitochondrial Control of Apoptosis  |  PI3K/Akt Signaling
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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14-3-3 gamma

Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  InnateDB