14-3-3 gamma
Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. Belongs to the 14-3-3 family. Highly expressed in brain, skeletal muscle, and heart. Note: This description may include information from UniProtKB.
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Protein type: Adaptor/scaffold |
Chromosomal Location of human Ortholog: 7q11.23 |
Cellular Component:
cytoplasm; cytosol; presynapse
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Molecular Function:
identical protein binding; insulin-like growth factor receptor binding; protein binding; protein domain specific binding; protein kinase C binding; protein kinase C inhibitor activity; receptor tyrosine kinase binding
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Biological Process:
cellular response to insulin stimulus; negative regulation of protein kinase activity; protein targeting; regulation of neuron differentiation; regulation of signal transduction; regulation of synaptic plasticity; signal transduction
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Disease: Epileptic Encephalopathy, Early Infantile, 56
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Reference #:
P61981
(UniProtKB)
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Alt. Names/Synonyms: 14-3-3 gamma; 14-3-3 protein gamma; 14-3-3 protein gamma, N-terminally processed; 14-3-3GAMMA; 1433G; EIEE56; KCIP-1; PPP1R170; Protein kinase C inhibitor protein 1; protein phosphatase 1, regulatory subunit 170; tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein gamma; tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide; YWHAG
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Gene Symbols: YWHAG
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Molecular weight:
28,303 Da
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Basal Isoelectric point:
4.8
Predict pI for various phosphorylation states
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CST Pathways:
Apoptosis Regulation
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G2/M DNA Damage Checkpoint
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Growth And Differentiation Control by MAPKs
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Mitochondrial Control of Apoptosis
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PI3K/Akt Signaling
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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