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SMRT
Transcriptional corepressor. Mediates the transcriptional repression activity of some nuclear receptors by promoting chromatin condensation, thus preventing access of the basal transcription. Isoform 1 and isoform 4 have different affinities for different nuclear receptors. Involved in the regulation BCL6-dependent of the germinal center (GC) reactions, mainly through the control of the GC B-cells proliferation and survival. Recruited by ZBTB7A to the androgen response elements/ARE on target genes, negatively regulates androgen receptor signaling and androgen-induced cell proliferation. Belongs to the N-CoR nuclear receptor corepressors family. Ubiquitous. High levels of expression are detected in lung, spleen and brain. 4 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: Nuclear receptor co-regulator; Transcription, coactivator/corepressor |
| Chromosomal Location of Human Ortholog: 5|5 G1.1 |
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Cellular Component:
chromatin; histone deacetylase complex; nuclear body; nuclear chromatin; nuclear matrix; nucleoplasm; nucleus; transcriptional repressor complex
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Molecular Function:
chromatin binding; DNA binding; glucocorticoid receptor binding; histone deacetylase binding; Notch binding; nuclear hormone receptor binding; nuclear receptor binding; protein binding; protein N-terminus binding; protein-containing complex binding; retinoic acid receptor binding; retinoid X receptor binding; RNA polymerase II regulatory region DNA binding; sequence-specific DNA binding; transcription corepressor activity
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Biological Process:
cell proliferation in forebrain; forebrain development; glucose homeostasis; heart morphogenesis; in utero embryonic development; negative regulation of androgen receptor signaling pathway; negative regulation of fat cell differentiation; negative regulation of production of miRNAs involved in gene silencing by miRNA; negative regulation of transcription by RNA polymerase II; negative regulation of transcription, DNA-templated; positive regulation of protein deacetylation; regulation of cellular ketone metabolic process by negative regulation of transcription from RNA polymerase II promoter; telencephalon development; type I pneumocyte differentiation; white fat cell differentiation
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Reference #:
Q9WU42
(UniProtKB)
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Alt. Names/Synonyms: N-CoR; N-CoR2; Ncor2; nuclear receptor co-repressor 2; Nuclear receptor corepressor 2; Silencing mediator of retinoic acid and thyroid hormone receptor; silencing mediator of retinoid acid and thyroid hormone receptor; SMR; SMRT; SMRTe; T3 receptor-associating factor; Thyroid-, retinoic-acid-receptor-associated corepressor; TRAC
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Gene Symbols: Ncor2
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Molecular weight:
269,807 Da
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Basal Isoelectric point:
7
Predict pI for various phosphorylation states
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CST Pathways:
Notch Signaling
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Protein Acetylation
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