SMRT Transcriptional corepressor. Mediates the transcriptional repression activity of some nuclear receptors by promoting chromatin condensation, thus preventing access of the basal transcription. Isoform 1 and isoform 4 have different affinities for different nuclear receptors. Involved in the regulation BCL6-dependent of the germinal center (GC) reactions, mainly through the control of the GC B-cells proliferation and survival. Recruited by ZBTB7A to the androgen response elements/ARE on target genes, negatively regulates androgen receptor signaling and androgen-induced cell proliferation. Belongs to the N-CoR nuclear receptor corepressors family. Ubiquitous. High levels of expression are detected in lung, spleen and brain. 4 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Nuclear receptor co-regulator; Transcription, coactivator/corepressor
Chromosomal Location of mouse Ortholog: 5|5 G1.1
Cellular Component:  chromatin; histone deacetylase complex; nuclear body; nuclear matrix; nucleoplasm; nucleus; transcription repressor complex
Molecular Function:  chromatin binding; DNA binding; histone deacetylase binding; Notch binding; nuclear glucocorticoid receptor binding; nuclear receptor binding; nuclear retinoic acid receptor binding; nuclear retinoid X receptor binding; protein binding; protein-containing complex binding; sequence-specific DNA binding; sequence-specific double-stranded DNA binding; transcription corepressor activity
Biological Process:  cell proliferation in forebrain; epidermis development; establishment of skin barrier; forebrain development; gene expression; glucose homeostasis; heart morphogenesis; in utero embryonic development; negative regulation of androgen receptor signaling pathway; negative regulation of DNA-templated transcription; negative regulation of fat cell differentiation; negative regulation of miRNA transcription; negative regulation of transcription by RNA polymerase II; positive regulation of protein deacetylation; protein deacetylation; protein stabilization; regulation of cellular ketone metabolic process; telencephalon development; type I pneumocyte differentiation; white fat cell differentiation
Reference #:  Q9WU42 (UniProtKB)
Alt. Names/Synonyms: N-CoR; N-CoR2; Ncor2; nuclear receptor co-repressor 2; Nuclear receptor corepressor 2; Silencing mediator of retinoic acid and thyroid hormone receptor; silencing mediator of retinoid acid and thyroid hormone receptor; SMR; SMRT; SMRTe; T3 receptor-associating factor; Thyroid-, retinoic-acid-receptor-associated corepressor; TRAC
Gene Symbols: Ncor2
Molecular weight: 269,807 Da
Basal Isoelectric point: Predict pI for various phosphorylation states
CST Pathways:  Notch Signaling  |  Protein Acetylation
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  Reactome  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene  |  NURSA  |  Ensembl Protein